East Hills, NY (October 17, 2005) - - Research studies demonstrating the effectiveness of prion filtration technology to safeguard the blood supply are being presented at the AABB Annual Meeting in Seattle, Washington today. Prion diseases, such as variant Creutzfeldt-Jakob Disease (vCJD), the human form of Bovine Spongiform Encephalopathy or "mad cow" disease, are of growing concern to blood services worldwide because of the potential for transmission through transfusion from asymptomatic donors. Pall Corporation (NYSE: PLL) is presenting research results further validating the performance of its Leukotrap Affinity Prion Reduction Filter System, which was CE marked with a 99.9 percent prion removal efficiency in May 2005. It is the first technology that reduces infectious prions from red cells, the most widely transfused blood component.
A new study conducted by the American Red Cross and the Eastern Virginia Medical School, Norfolk Va., et.al., found that red blood cells filtered through the Leukotrap Affinity Prion Reduction Filter System retain their therapeutic value and quality after 42 days of storage. The samples tested showed mean values of 85.0 and 82.9 percent in vivo red cell recovery, exceeding the FDA required mean of 75 percent for stored red cells. Post-storage hemolysis (breakdown of red cell membrane) values were well below the FDA maximum limit. The researchers concluded that both in vivo and in vitro results of this study indicate that leukoreduced red cell products filtered through the Pall system demonstrated acceptable quality for transfusion.
Sam Coker, Ph.D., Principal Scientist of Pall Corporation, presented results of research testing the filter against sporadic CJD, the most common form of prion disease that affects humans. The study, conducted with the Departments of Neurology, Psychiatry and Pathology of the New York University School of Medicine, showed a 99.9 percent reduction of the prion.
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