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Studies validating performance of Pall prion reduction technology presented at AABB

dy, a first with a true human form of prion disease, provides additional confirmation of the performance of our technology to remove all types of prions that can adversely affect people," said Dr. Coker. The sporadic CJD study is one of a series of studies underscoring the filter's capability in reducing all types of prions from blood, including scrapie (a prion disease affecting sheep) and mouse-adapted human vCJD.

Dr. Coker also presented the results of research on the performance characteristics of the Pall Leukotrap Affinity Prion Reduction Filter under a range of different blood processing conditions, which may vary by country and blood center. The results showed that the new filter was effective in removing infectious scrapie prions from different preparations of red cell concentrates at different temperatures. In addition to prion removal, the study also measured the level of leukocyte reduction (resulting in removal of about 5 logs) and the quality of red cells before and after filtration, showing that normal cell qualities were maintained.

Pall developed the Pall Leukotrap Prion Affinity Reduction Filter System to help blood authorities around the world stop the transmission of prions as part of the Company's mission to help safeguard the global blood supply. Its prion technology is currently under evaluation by the Irish Blood Transfusion Service and the English National Blood Service for integration into their respective practices as a blood safety measure to reduce the risk of vCJD prion transmission. Pall is continuing its prion research and development program to apply its technologies to meet the specific requirements of each nation throughout Europe, the epicenter of vCJD, followed by North America and Asia.


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Contact: Marcia Katz
marcia_katz@pall.com
516-801-9128
Pall Corporation
17-Oct-2005


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