HOME >> BIOLOGY >> NEWS
Study: Testing for joint substance in blood might improve diagnosis of osteoarthritis

B. Kraus, associate professor of medicine, and Thomas Stabler, both at Duke University, Dr. Charles D. Helmick of the Centers for Disease Control and Prevention and Dr. Marc C. Hochberg of the University of Maryland also participated in the study.

Hyaluronan is produced by cells of what is called the extracellular matrix, Jordan said. It is thought to contribute to lubricating joints, a process without which walking and running would be unbearably painful. Earlier work suggested HA might serve as a sign, or biomarker, of osteoarthritis.

"Our study is unique in that it consisted of a large, ethically diverse, population-based sample of African Americans and Caucasians and incorporates five definitions of osteoarthritis as shown on X rays," she said. "This was the first study of hyaluronan and osteoarthritis to include African Americans and to consider how other health problems commonly occurring with osteoarthritis might confound the relationship between serum HA and osteoarthritis."

The researchers studied 753 subjects, including 455 with osteoarthritis in their knees. Volunteers ranged in age from about 51 to 72 and averaged almost 62. About 39 percent suffered from high blood pressure, the most common other illness. The least common was cancer.

Average serum HA levels correlated with age, Jordan said. Whites and men showed higher levels than blacks and women, which could reflect genetic or physiologic factors. Such sex and racial differences would need to be taken into account when determining the usefulness of HA and other potential biomarker testing.

Medical scientists have known for the past decade that levels of an important protein known as COMP were higher in cartilage, ligaments, tendons and joint lubricating fluid of whites with osteoarthritis than in whites without the painful, degenerative illness, Jordan said.

In 2003, she and her UNC colleagues showed for the first time that the same th
'"/>

Contact: David Williamson
919-962-8596
University of North Carolina at Chapel Hill
24-Feb-2005


Page: 1 2 3

Related biology news :

1. Study: Sticking to the sand might not be such good, clean fun for beachgoers
2. Study: Donated embryos could result in more than 2,000 new embryonic stem cell lines
3. Study: Chest compressions without mouth-to-mouth better for out-of-hospital cardiac arrest
4. Study: Long legs are more efficient
5. Study: Living coral reefs provide better protection from tsunami waves
6. Study: Rain forest insects eat no more tree species than temperate counterparts
7. Study: Newer antibiotic more effective at treating elders pneumonia
8. Study: Competition for sex is a jungle out there
9. Study: Temperate forests could worsen global warming
10. Study: Arctic undergoing holistic climate-change response
11. Study: Run-down feeling with illness may last longer as people age

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/11/2020)... ... February 11, 2020 , ... Modality Solutions, ... achieved its ISO 9001:2015 registration by certification body Intertek. Modality Solutions’ Quality Manager, ... and revised all existing Standard Operating Procedures (SOPs) and created ten new SOPs. ...
(Date:2/11/2020)... , ... February 11, 2020 , ... ... into The LaunchPort™ medical device accelerator in Port Covington, Baltimore. The newly formed ... that must be addressed to manage increased demand for home dialysis treatments. The ...
(Date:2/7/2020)... ... February 07, 2020 , ... dicentra , a leading ... nutraceutical and dietary supplement industries, announces 2020 membership with the International Probiotics Association ... research pertaining to probiotics. We are thrilled to join our IPA member colleagues ...
Breaking Biology News(10 mins):
(Date:2/10/2020)... ... , ... R3 Medical Training announced it is now registering for its next ... course is hands on involving real patients and stem cell biologics, with every attendee ... Cell Training Course has received rave reviews from attendees, who love the hands on ...
(Date:2/5/2020)... Fla. (PRWEB) , ... February 05, 2020 , ... ... annual observance, sponsored by The National Organization for Rare Disorders (NORD), to raise awareness ... lives ( rarediseaseday.org ). The Balancing Act’s “Behind The Mystery” rare disease ...
(Date:2/3/2020)... ... February 03, 2020 , ... Global molecular ... that OmniType, the 11-locus, single tube multiplex successor to Holotype HLA is available ... featuring locus-multiplexing and short library preparation, for HLA genotyping from sample to answer ...
(Date:1/28/2020)... ... January 28, 2020 , ... ... solutions for biopharmaceutical R&D, today announced the release of Genedata Expressionist ... on supporting the implementation of Multi-Attribute Methods (MAM) for characterizing and monitoring ...
Breaking Biology Technology:
Cached News: