HOME >> BIOLOGY >> NEWS
Study advances evidence for receptor's role in alcohol pleasure and problems

A genetic variant of a receptor in the brains reward circuitry heightens the stimulating effects of early exposures to alcohol and increases alcohol consumption, according to a new study by researchers at the National Institute on Alcohol Abuse and Alcoholism (NIAAA), part of the National Institutes of Health (NIH). Conducted in rhesus monkeys, the study extends previous research that suggests an important role for a similar brain receptor variant in the development of human alcohol use disorders. A report of the findings is published in the March, 2007 issue of the Archives of General Psychiatry.

"Although the pathway to alcoholism is influenced by many factors, our findings affirm that individuals who possess this receptor variant may experience enhanced pleasurable effects from alcohol that could increase their risk for developing alcohol abuse and dependence," notes Markus Heilig, M.D., Ph.D., NIAAA Clinical Director and the studys senior author.

Molecules known as opioid peptides bind to opioid receptors in the brain to signal experiences of reward and reinforcement, as well as the euphoria and other positive subjective effects produced by alcohol. Previous studies have shown that, among the brains various subtypes of opioid receptors, the mu-subtype is most likely responsible for transmitting alcohols positive effects.

"We also know that there are several genetic variants of the human mu-opioid receptor," notes first author Christina Barr, V.M.D., Ph.D., a lead investigator in NIAAAs Laboratory of Clinical and Translational Studies and Laboratory of Neurogenetics. "One of these, designated 118G, has a greatly enhanced ability to bind opioid peptides. People who have this variant of the receptor have reported increased euphoria following alcohol consumption."

Drs. Barr, Heilig, and their colleagues note that recent studies have linked the 118G mu-opioid receptor with alcohol dependence in humans. In the current s
'"/>

Contact: John Bowersox
jbowersox@niaaa.nih.gov
301-443-3860
NIH/National Institute on Alcohol Abuse and Alcoholism
6-Mar-2007


Page: 1 2 3

Related biology news :

1. Study begins to reveal clues to the cause and progression of sepsis
2. Study finds gender differences in renal and other genes contributing to blood pressure
3. Study suggests estrogen deficiency can lead to obesity-induced high blood pressure after menopause
4. Study: Sticking to the sand might not be such good, clean fun for beachgoers
5. Study points to new way to predict death risk from torn aorta
6. Study identifies new gene therapy tools for inherited blindness
7. Study finds contaminated water reaching Floridas offshore keys
8. Study sheds light on why humans walk on two legs
9. Study explains how pathogens evolve to escape detection
10. Study finds hereditary link to premenstrual depression
11. Study identifies energy efficiency as reason for evolution of upright walking

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/28/2020)... and FORT WORTH, Texas (PRWEB) , ... May ... ... stage biopharmaceutical company, announced today that interim results from their 1801 Phase 1/2 ... of Clinical Oncology (ASCO) Annual Meeting which will take place virtually on May ...
(Date:5/21/2020)... ... May 19, 2020 , ... ... today introduced BioMed to their award-winning computerized maintenance management system (CMMS), TheWorxHub™. ... and systems around biomedical engineering to better allocate staff time, automate assignments, ...
(Date:5/15/2020)... ... 2020 , ... The National Institutes of Health (NIH) has selected McBee Moore ... and Tysons Corner, Virginia, to provide patent legal services under two separate ten (10) ... of chemistry. The firm is one of nine firms in the nation awarded a ...
Breaking Biology News(10 mins):
(Date:4/7/2020)... (PRWEB) , ... April 06, 2020 , ... ... process solutions for the life sciences industry, has announced the release of at-home ... quickly, our top priority is the health and safety of our employees as ...
(Date:4/1/2020)... ... March 30, 2020 , ... A joint ... Diagnostics (RID), formed earlier this year to bring telehealth to various government agencies, ... for COVID-19. Company officials are currently?awaiting an Emergency Use Authorization (EUA) waiver from ...
(Date:4/1/2020)... ... March 31, 2020 , ... Carterra® Inc., the world ... (LJI), announced today that they will use Carterra’s proprietary LSA™ platform to screen hundreds ... the clinic as early as this summer. , La Jolla Institute for Immunology ...
(Date:3/27/2020)... , ... March 25, 2020 ... ... the opening of its veterinary histopathology laboratory located centrally in the midwest ... the ability to work with a highly motivated, independent, professional team that ...
Breaking Biology Technology:
Cached News: