HOME >> BIOLOGY >> NEWS
Study advances vCJD prion detection

Scientists have made significant advances towards the development of a technique that could be used to confirm whether someone is infected with variant CJD.

The technique, which has so far been used mainly in animal models, works by mimicking and accelerating the replication of prions - abnormal proteins that progressively kill off brain tissue and are thought to cause the disease.

The method, known as known as Protein Misfolding Cyclic Amplification (PMCA), enables the level of prions to be increased so that they can be recognised by existing detection methods.

Researchers have shown for the first time that the number of vCJD prions can be amplified from infected human brain tissue extracts prepared from normal human platelets - a type of blood cell essential for clotting.

The sample is incubated and exposed to repeated rounds of ultrasound, which break the prions up into more numerous smaller particles.

The research was carried out by the University of Edinburgh National CJD Surveillance Unit working with the Scottish National Blood Transfusion Service, the Neuropathogenis Unit at the Roslin Institute and CSL Behring,

However, more research is urgently needed to ensure that the technique, which has been applied to brain tissue, can be applied to other tissues, such as blood, that might be used in tests for vCJD.

Professor James Ironside, of the National CJD Surveillance Unit at the University of Edinburgh, said: While this method, due to the length of time it takes to carry out, is unlikely to produce a rapid screening test that could be implemented in blood donation centres it may well be suitable as a confirmatory test that could be conducted at a national centre.

Work is currently ongoing to develop a screening test for vCJD but one of the issues common to various screening tests is that of false positive results. By developing a reliable confirmatory test, such as this one
'"/>

Contact: Tara Womersley
tara.womersley@ed.ac.uk
44-131-650-9836
University of Edinburgh
5-Jul-2007


Page: 1 2

Related biology news :

1. Study begins to reveal clues to the cause and progression of sepsis
2. Study finds gender differences in renal and other genes contributing to blood pressure
3. Study suggests estrogen deficiency can lead to obesity-induced high blood pressure after menopause
4. Study: Sticking to the sand might not be such good, clean fun for beachgoers
5. Study points to new way to predict death risk from torn aorta
6. Study identifies new gene therapy tools for inherited blindness
7. Study finds contaminated water reaching Floridas offshore keys
8. Study sheds light on why humans walk on two legs
9. Study explains how pathogens evolve to escape detection
10. Study finds hereditary link to premenstrual depression
11. Study identifies energy efficiency as reason for evolution of upright walking

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/11/2017)... 2017 No two people are believed ... New York University Tandon School of Engineering and ... that partial similarities between prints are common enough ... phones and other electronic devices can be more ... lies in the fact that fingerprint-based authentication systems ...
(Date:4/5/2017)... April 5, 2017  The Allen Institute for Cell ... Explorer: a one-of-a-kind portal and dynamic digital window into ... data, the first application of deep learning to create ... cell lines and a growing suite of powerful tools. ... these and future publicly available resources created and shared ...
(Date:4/4/2017)... , April 4, 2017   EyeLock LLC ... announced that the United States Patent and Trademark Office ... broadly covers the linking of an iris image with ... transaction) and represents the company,s 45 th issued ... patent is very timely given the multi-modal biometric capabilities ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... ... October 11, 2017 , ... ... has granted orphan drug designation to SBT-100, its novel anti-STAT3 (Signal Transducer and ... of osteosarcoma. SBT-100 is able to cross the cell membrane and bind intracellular ...
(Date:10/10/2017)... ... October 10, 2017 , ... For the second ... a US2020 STEM Mentoring Award. Representatives of the FirstHand program travelled to Washington, ... from US2020. , US2020’s mission is to change the trajectory of STEM education ...
(Date:10/10/2017)... SANTA CRUZ, Calif. , Oct. 10, 2017 /PRNewswire/ ... SBIR grant from the NIH to develop RealSeq®-SC (Single ... preparation kit for profiling small RNAs (including microRNAs) from ... Cell Analysis Program highlights the need to accelerate development ... "New techniques for ...
(Date:10/9/2017)... , Oct. 9, 2017  BioTech Holdings ... mechanism by which its ProCell stem cell therapy ... limb ischemia.  The Company, demonstrated that treatment with ... of limbs saved as compared to standard bone ... molecule HGF resulted in reduction of therapeutic effect.  ...
Breaking Biology Technology:
Cached News: