Study begins to reveal clues to the cause and progression of sepsis

st, and far longer than the courses of therapies used in unsuccessful clinical trials of experimental agents, said John A. Kellum, M.D., professor, department of critical care medicine, University of Pittsburgh School of Medicine. We also found that the difference between the inflammatory response in a patient with a good outcome and a patient with a bad outcome is only a matter of degree.

The Pitt researchers say that in light of their results, treatments that completely abolish a specific component of the inflammatory response would be ineffective, and could be dangerous, since the inflammatory response is needed to address the underlying infection. Instead, they believe that therapies that address the chronic inflammatory response after sepsis and those that act more broadly on multiple components may yield better results.

No one really knows why some people develop sepsis following an infection, said Scott Somers, Ph.D., who oversees sepsis grants at the National Institute of General Medical Sciences, which partially funded the work. This large study gives us a much clearer picture of sepsisand shows us that its even more complicated than we thought.

The researchers plan to release several other reports from the GenIMS study in the coming months, which they hope will provide more clues to the condition.


Contact: Jocelyn Uhl Duffy
University of Pittsburgh Schools of the Health Sciences

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