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Study could help transplant surgeons predict rejection/tailor medications

ons, known as nucleotide polymorphisms, represent "misspellings" in the genetic code, are present in all people and form the basis of inherited predisposition to a variety of diseases and outcomes, according to Dr. Sindhi.

"There is evidence from our earlier research that these mutations can be transmitted from parent to child in certain patterns that indicate if a transplant candidate is predisposed to rejection, a rejection-free state or tolerance, a rare occurrence whereby anti-rejection medications no longer are required," he said. "Any tool that could help guide us in deciding when and by how much to lower anti-rejection medications would be invaluable in improving the quality of life for our patients."


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Contact: Marc Lukasiak
marc.lukasiak@chp.edu
412-692-7919
Children's Hospital of Pittsburgh
11-Oct-2006


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