HOME >> BIOLOGY >> NEWS
Study describes how cells return to normal after responding to stress

(Embargoed) CHAPEL HILL -- New research from the University of North Carolina at Chapel Hill School of Medicine describes how cells recover from heat, cold and other stressful conditions.

The findings also could have implications for the development of new therapies for cardiovascular diseases and neurodegenerative diseases such as Alzheimer's.

The study, which appears in the March 23 issue of Nature, was led by Dr. Cam Patterson, Ernest and Hazel Craige distinguished professor of cardiovascular medicine, chief of the Division of Cardiology and director of the Carolina Cardiovascular Biology Center. Patterson also is a member of the UNC Lineberger Comprehensive Cancer Center.

The research explores the role played by the protein CHIP in the cell's response to stress. The Patterson laboratory cloned the protein in 1999.

In the setting of stress, molecules known as heat shock proteins are synthesized by the cell to provide protection against protein damage. These heat shock proteins, Hsp's, are an important part of a large protein family known as molecular chaperones. Molecular chaperones help new or distorted proteins fold into the correct shape, which is essential to their function.

"Molecular chaperones determine whether proteins are appropriately folded," Patterson said. "They help proteins to fold normally when proteins are being made, and they help the cell to find damaged proteins under stressful circumstances. Once those damaged proteins are found, the cell either tries to refold them or to get rid of them somehow."

CHIP is a co-chaperone, meaning that it associates with the molecular chaperone Hsp70 and regulates its activity. But CHIP also has another function as an ubiquitin ligase.

"Ubiquitin ligases are generally involved in tagging proteins with a signal that allows them to be recognized by the proteasome, which is the major garbage can for proteins in a cell," Patterson said. "Our model is that CHIP is the p
'"/>

Contact: L.H. Lang
llang@med.unc.edu
919-843-9687
University of North Carolina School of Medicine
22-Mar-2006


Page: 1 2 3

Related biology news :

1. Study begins to reveal clues to the cause and progression of sepsis
2. Study finds gender differences in renal and other genes contributing to blood pressure
3. Study suggests estrogen deficiency can lead to obesity-induced high blood pressure after menopause
4. Study: Sticking to the sand might not be such good, clean fun for beachgoers
5. Study points to new way to predict death risk from torn aorta
6. Study identifies new gene therapy tools for inherited blindness
7. Study finds contaminated water reaching Floridas offshore keys
8. Study sheds light on why humans walk on two legs
9. Study explains how pathogens evolve to escape detection
10. Study finds hereditary link to premenstrual depression
11. Study identifies energy efficiency as reason for evolution of upright walking

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/13/2020)... ... February 13, 2020 , ... Strategic Directions International ... Laboratory Analytical & Life Science Instrumentation Industry. The report will be released on ... market intelligence for the $70 billion laboratory market for analytical and life science ...
(Date:2/11/2020)... (PRWEB) , ... February 11, 2020 , ... ... moved into The LaunchPortâ„¢ medical device accelerator in Port Covington, Baltimore. The newly ... issues that must be addressed to manage increased demand for home dialysis treatments. ...
(Date:2/5/2020)... ... February 04, 2020 , ... ... (USPTO) issued the company a second patent related to proprietary liquid crystal technology ... compliments another patent from the USPTO issued on December 3, 2019. Together, these ...
Breaking Biology News(10 mins):
(Date:1/22/2020)... SAN MATEO, Calif. (PRWEB) , ... January 20, ... ... Home System, today announced a partnership with WAVE Electronics, the largest independent electronics ... their installer partners to purchase Brilliant Smart Home Systems with leading smart home ...
(Date:1/22/2020)... ... 21, 2020 , ... COBO Technologies and Cardea Bio partner ... have agreed to co-develop and market a portfolio of CRISPR QC products and ... the longer-term, the parties aim to develop a COBO branded QC device based ...
(Date:1/10/2020)... (PRWEB) , ... January 09, 2020 , ... ... of Drug Development establishes benchmarks for the vendor qualification process, a critical ... Report, the process volume and complexity of the vendor qualification process creates delays ...
(Date:1/10/2020)... N.J. (PRWEB) , ... January 09, 2020 , ... ... in China, today announced its inaugural GenScript Biotech Global Forum on Jan. 14 ... exploring the theme "Cell and Gene Therapy and the Booming China Market," will ...
Breaking Biology Technology:
Cached News: