HOME >> BIOLOGY >> NEWS
Study fails to verify gene variations as risk factors for certain cardiovascular problems

New research has failed to confirm findings from smaller studies that 85 gene variations are associated with an increased risk for acute coronary syndromes (ACS), which includes heart attack and a type of angina, according to a study in the April 11 issue of JAMA.

Previous studies have identified a number of genetic variations as potential cardiovascular risk factors, but few, if any, have been established definitively. "Before use in clinical care, potential genetic risk factors would ideally be replicated en masse in large, well-characterized patient populations. To date, no such comprehensive validation of genetic variants potentially associated with ACS or atherosclerosis has been reported," the authors write.

Thomas M. Morgan M.D., formerly of the Yale University School of Medicine, New Haven, Conn., and colleagues conducted a study to validate genetic risk factors for ACS. The researchers identified genetic variants previously reported as significant susceptibility factors for atherosclerosis or ACS through a literature search of published articles. This study included 811 patients with ACS and 650 age- and sex-matched controls who were genotyped for 85 variants in 70 genes and attempted to replicate previously reported associations.

Of 85 variants tested, only one of the gene variants was nominally statistically significant. Only four additional genes were positive in model-free analysis. Neither number of associations was more frequent than expected by chance, given the number of comparisons. Only 41 of 84 predefined risk variants were even marginally more frequent in cases than in controls (with 1 tie).

"We were unable to confirm as risk factors for ACS 85 genetic variants because none were unequivocally validated in this large case-control study of 1,461 participants," the authors write. "We therefore conclude that our findings, in this large sample of well-characterized ACS patients and controls, cannot support
'"/>

Contact: Diane Duke Williams
314-286-0111
JAMA and Archives Journals
10-Apr-2007


Page: 1 2

Related biology news :

1. Study begins to reveal clues to the cause and progression of sepsis
2. Study finds gender differences in renal and other genes contributing to blood pressure
3. Study suggests estrogen deficiency can lead to obesity-induced high blood pressure after menopause
4. Study: Sticking to the sand might not be such good, clean fun for beachgoers
5. Study points to new way to predict death risk from torn aorta
6. Study identifies new gene therapy tools for inherited blindness
7. Study finds contaminated water reaching Floridas offshore keys
8. Study sheds light on why humans walk on two legs
9. Study explains how pathogens evolve to escape detection
10. Study finds hereditary link to premenstrual depression
11. Study identifies energy efficiency as reason for evolution of upright walking

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/13/2019)... (PRWEB) , ... June 13, 2019 , ... KICVentures ... of Spine & The Spine, Orthopedic and Pain Management-Driven ASC Conference in Chicago on ... & Resorts 323 E. Wacker Dr. Chicago, IL in the 3rd floor Ticino Hospitality ...
(Date:6/11/2019)... ... June 12, 2019 , ... ... services, Abveris plans to leverage the Geneious Biologics platform as a premium hub ... Technology Officer at Abveris, says: “The Geneious team has done an excellent job ...
(Date:6/6/2019)... (PRWEB) , ... June 05, 2019 , ... ... top companies and solutions in the global health and medical technology market, announced ... its “Best Healthcare Navigation / Robotics Solution” award in the 2019 MedTech Breakthrough ...
Breaking Biology News(10 mins):
(Date:5/31/2019)... TORONTO (PRWEB) , ... May 29, 2019 , ... For ... but the toughest forms of cancer demand breakthrough therapies. Advances in immuno-oncology have led ... a patient’s own T cells with engineered T cell receptors known as “CARs”. The ...
(Date:5/31/2019)... ... , ... World Compliance Seminars today announced a live seminar ... MA. This peer recommended interactive workshop is always selected by professionals at global ... with a compendial treatment of Data Integrity fundamentals. After laying the groundwork, the ...
(Date:5/31/2019)... ... 30, 2019 , ... A study released today in STEM ... the sustained release of human placental stem cell (HPSC)-derived conditioned medium (CM) to ... CM into the injured kidney, where it helped restore function and regenerate injured ...
(Date:5/21/2019)... ... May 21, 2019 , ... ... today officially opened the inaugural Africa Brewing Conference dedicated to sharing brewing knowledge, ... Africa. The event, which is supported through a partnership with “Ethiopia Invest”, will ...
Breaking Biology Technology:
Cached News: