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Study finds Western-style 'meat-sweet' diet increases risk of breast cancer in postmenopausal women

PHILADELPHIA A new study finds that the more western the diet -- marked by red meat, starches and sweets -- the greater the risk for breast cancer among postmenopausal Chinese women. According to researchers who conducted the analysis at Fox Chase Cancer Center in Philadelphia, Harvard University, Shanghai Cancer Institute, and Vanderbilt University, the findings mark the first time a specific association between a western diet and breast cancer has been identified in Asian women.

The study, published in the July issue of Cancer Epidemiology, Biomarkers & Prevention, a journal of the American Association for Cancer Research, is the latest set of findings derived from the Shanghai Breast Cancer Study, conducted in the 1990s by Wei Zheng, M.D., Ph.D., M.P.H, and colleagues at Vanderbilt University. The Fox Chase researchers identified dietary habits among women in the study based on their reported eating habits, classifying them as either meat-sweet or vegetable-soy eaters.

The Shanghai data gave us a unique look at a population of Chinese women who were beginning to adopt more western-style eating habits, said, Marilyn Tseng, Ph.D. associate member in the population science division at Fox Chase. We found an association between a western-style diet and breast cancer was pronounced in postmenopausal women, especially heavier women with estrogen receptor-positive tumors.

Breast cancers marked by the excessive production of estrogen receptors (ER+ breast cancers) form the majority of breast cancers and are often associated with obesity. According to Tseng, there seems to be a specific interaction between obesity and western cuisine among postmenopausal women that drives breast cancer, although the study did not offer a specific mechanism.

Tseng and her colleagues examined cases of women from the Shanghai Breast Cancer Study, 25 to 64 years of age, who were newly diagnosed with breast cancer from August 1996 to March 1998
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Contact: Greg Lester
lester@aacr.org
267-646-0554
American Association for Cancer Research
10-Jul-2007


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