HOME >> BIOLOGY >> NEWS
Study identifies 5 genetic themes key to keeping stem cells in a primitive, flexible state

For more than 25 years, stem cells have been defined based on what they can become: more of themselves, as well as multiple different specialized cell types. But as genetic techniques have become increasingly powerful, many scientists have sought a more molecular definition of stem cells, based on the genes they express.

Now, a team of Canadian scientists has identified 1,155 genes under the control of a gene called Oct4 considered to be the master regulator of the stem cell state. A comprehensive molecular definition of stem cells is emerging: according to this research, stem cells are cells that keep their DNA packaged in a flexible format, keep cell division tightly controlled, prevent signals that might trigger death, repair DNA very effectively, and reinforce all of these characteristics by tightly controlling how molecules can move within the nucleus. The study will be published in the June 20 edition of the online, open-access journal PLoS ONE.

You could call this a theory-of-everything for stem cells, said senior author Dr. Michael Rudnicki, referring to the often-cited theory of everything for physics. Dr. Rudnicki is a Senior Scientist and Professor at the Ottawa Health Research Institute and the University of Ottawa. He also leads the Sprott Centre for Stem Cell Research in Ottawa and Canadas Stem Cell Network.

While previous studies have tried to compare gene expression in different types of stem cells, the strategy used in this study was unique. Rather than simply searching for any genes expressed by stem cells, the researchers looked for genes whose expression was also correlated with the master stem cell regulator gene Oct4. They also applied very rigorous analysis methods, using data from StemBase, the largest stem cell gene expression database in the world. Designed by bioinformaticist Dr. Miguel Andrade, the database includes data from thousands of DNA microarrays submitted mainly by scientists in Canadas Stem Cel
'"/>

Contact: Jennifer Paterson
jpaterson@ohri.ca
613-798-5555
Public Library of Science
19-Jun-2007


Page: 1 2

Related biology news :

1. Study begins to reveal clues to the cause and progression of sepsis
2. Study finds gender differences in renal and other genes contributing to blood pressure
3. Study suggests estrogen deficiency can lead to obesity-induced high blood pressure after menopause
4. Study: Sticking to the sand might not be such good, clean fun for beachgoers
5. Study points to new way to predict death risk from torn aorta
6. Study identifies new gene therapy tools for inherited blindness
7. Study finds contaminated water reaching Floridas offshore keys
8. Study sheds light on why humans walk on two legs
9. Study explains how pathogens evolve to escape detection
10. Study finds hereditary link to premenstrual depression
11. Study identifies energy efficiency as reason for evolution of upright walking

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:12/13/2018)... ... December 12, 2018 , ... New research by Florida Polytechnic University faculty ... and distracted driving, one of the main causes of car accidents and fatalities on ... Kanwal Gagneja , assistant professor of computer science, uses a microcomputer, a camera, and ...
(Date:12/10/2018)... ... December 10, 2018 , ... ... to advance their shared goal of accelerating the development of the Regenerative Medicine ... systems to TRT’s core technology around human umbilical cord perivascular cells (HUCPVCs). ...
(Date:12/5/2018)... VANCOUVER, British Columbia (PRWEB) , ... December 05, ... ... at The Royal Society of Medicine’s Photodynamic Therapy symposium 2018, London, England. The ... and addressed the scientific basis of PDT and its benefits in clinical practice ...
Breaking Biology News(10 mins):
(Date:12/13/2018)... FRANKLIN, Wis. (PRWEB) , ... December 13, 2018 ... ... HACCP scope which now includes food (human) ingredient. This has been part of ... Having a Food Safety Plan and certification creates custom fermentation opportunities for MDG ...
(Date:12/5/2018)... ... December 05, 2018 , ... STRmix™ – sophisticated forensic software ... – has been used to convict a Wyoming man of third-degree sexual assault, a ... used STRmix™ to test for DNA on the couch cushions on which the sexual ...
(Date:11/27/2018)... ... 2018 , ... New patients in need of a dental crown ... or without a referral. Dr. Myers has many years of experience improving patient smiles ... and custom crowns. , As a dedicated cosmetic dentist , Dr. Myers ...
(Date:11/20/2018)... ... 20, 2018 , ... Each year Forbes receives thousands of nominations for candidates ... performance by individuals under 30 years of age. The Forbes 30 Under 30 list ... Entertainment to Venture Capital and Science. , In 2017, Visikol CEO Dr. Michael ...
Breaking Biology Technology:
Cached News: