HOME >> BIOLOGY >> NEWS
Study identifies common flaws in oncology microarray studies

A substantial percentage of microarray-based studies in oncology contain critical flaws in analysis or in their conclusions, reports a study in the January 17 issue of the Journal of the National Cancer Institute. The study's authors provide a checklist and a set of guidelines for performing and reporting such studies.

Microarrays are a tool used to study gene expression. Researchers can study thousands of genes at a time, all on a single glass slide. In oncology, scientists have used microarrays to study unique gene expression patterns of specific tumor types, to discover new drug targets, and to categorize unique characteristics of a particular tumor to help doctors tailor treatments to an individual patient. However, such studies produce volumes of data that is easily misinterpreted. It has been difficult to replicate such studies, which is considered the best way to validate scientific findings.

To study the statistical methods used in cancer-focused microarray studies, Alain Dupuy, M.D., and Richard M. Simon, D.Sc., of the National Cancer Institute in Bethesda, Md., reviewed 90 studies published through the end of 2004 that related microarray expression profiling to clinical outcome. The most common cancers in those studies were hematologic malignancies (24 studies), lung cancer (12 studies), and breast cancer (12 studies). The studies fell into three general categories: an outcome-related gene finding, such as searching for specific genes that are expressed differently in people who have a good versus bad prognosis; a class discovery, where researchers cluster together tumors with similar gene expression profiles; and supervised prediction, in which the gene expression profiles are used to generate an algorithm or set of rules that will predict clinical outcomes for patients based on their individual gene expression profiles.

The authors closely scrutinized the statistical methods and reporting in 42 studies published in
'"/>

Contact: Andrea Widener
jncimedia@oxfordjournals.org
301-841-1287
Journal of the National Cancer Institute
16-Jan-2007


Page: 1 2

Related biology news :

1. Study begins to reveal clues to the cause and progression of sepsis
2. Study finds gender differences in renal and other genes contributing to blood pressure
3. Study suggests estrogen deficiency can lead to obesity-induced high blood pressure after menopause
4. Study: Sticking to the sand might not be such good, clean fun for beachgoers
5. Study points to new way to predict death risk from torn aorta
6. Study identifies new gene therapy tools for inherited blindness
7. Study finds contaminated water reaching Floridas offshore keys
8. Study sheds light on why humans walk on two legs
9. Study explains how pathogens evolve to escape detection
10. Study finds hereditary link to premenstrual depression
11. Study identifies energy efficiency as reason for evolution of upright walking

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Study identifies common flaws oncology microarray studies

(Date:3/23/2015)... --NXT-ID, Inc. (NASDAQ: NXTD ) ("NXT-ID" or the "Company"), ... market, announces its biometric payment technology, the Wocket® smart wallet, ... March 30 th . The new ... York markets. Gino Pereira ... new ad campaign following the recent initial shipment of Wocket ...
(Date:3/20/2015)... Markets ( http://www.researchandmarkets.com/research/rswjb4/hand_geometry ) has announced the addition ... report to their offering. This report analyzes ... report provides separate comprehensive analytics for the US, ... Europe , Asia-Pacific , ... Annual estimates and forecasts are provided for the period 2013 ...
(Date:3/20/2015)... Mar. 19, 2015 Research and Markets ( ... Biometrics - Global Strategic Business Report" report to their ... Iris Biometrics in US$ Thousands. The report provides separate comprehensive ... Japan , Europe , ... and Latin America . Annual ...
Breaking Biology News(10 mins):NXT-ID's Wocket Smart Wallet to Launch New CNBC Regional TV Ad Campaign 2NXT-ID's Wocket Smart Wallet to Launch New CNBC Regional TV Ad Campaign 3Hand Geometry - Global Strategic Business Report 2015: An Essential Security Component for both Government & Enterprise Sector 2Hand Geometry - Global Strategic Business Report 2015: An Essential Security Component for both Government & Enterprise Sector 3Hand Geometry - Global Strategic Business Report 2015: An Essential Security Component for both Government & Enterprise Sector 4Iris Biometrics - Global Strategic Business Report 2015: System & Network Access Control - A Robust Market Opportunity in the Offing 2Iris Biometrics - Global Strategic Business Report 2015: System & Network Access Control - A Robust Market Opportunity in the Offing 3Iris Biometrics - Global Strategic Business Report 2015: System & Network Access Control - A Robust Market Opportunity in the Offing 4Iris Biometrics - Global Strategic Business Report 2015: System & Network Access Control - A Robust Market Opportunity in the Offing 5
(Date:3/31/2015)... Orlando, Florida (PRWEB) March 31, 2015 ... announced the official relocation of their U.S. facilities and ... more than 25 years of experience, Cryos’ relocation is ... presence. , The move to Orlando was completed during ... with an official opening taking place on April 6. ...
(Date:3/31/2015)... California (PRWEB) March 31, 2015 ... consulting firm with operations in California, Oregon, Washington ... launch of its Merger and Acquisition (M&A) Integration ... Peter Adams, VP Client Services and M&A Integration ... shown that the vast majority of M&A initiatives ...
(Date:3/30/2015)... PMG Research, Benchmark Research, and ... formation of VaxCorps, a network of highly experienced, ... conduct of vaccine trials in healthy adult, elderly, ... successfully conducted over 500 phase I-III vaccine clinical ... influenza as well as a vast array of ...
(Date:3/30/2015)... CHICAGO , March 30, 2015  Heidrick & Struggles ... search , leadership consulting and culture shaping ... joined the firm to lead its global Healthcare and Life ... Healthcare and Life Sciences, Mitchell will lead a team of ... Europe and Asia ...
Breaking Biology Technology:Cryos International Completes Groundbreaking Sperm Migration to Orlando, Florida 2Lighthouse Information Systems, Inc., Announces Addition of M&A Integration Services 2PMG Research announces formation of VaxCorps with two industry-leading vaccine site networks 2Heidrick & Struggles Strengthens Leadership of Healthcare - Life Sciences Practice 2
Cached News: