HOME >> BIOLOGY >> NEWS
Study identifies gene in mice that may control risk-taking behavior in humans

SEATTLE One teenager likes to snowboard off a cliff. Another prefers to read a book and wouldn't think of trading places. Why these differences exist is a mystery, but for the first time researchers have identified a possible genetic explanation behind risk-seeking behavior.

Scientists at Fred Hutchinson Cancer Research Center have found that a specific neurodevelopmental gene, called neuroD2, is related to the development of an almond-shaped area of the brain called the amygdala, the brain's emotional seat. This gene also controls emotional-memory formation and development of the fear response, according to research led by James Olson, M.D., Ph.D., associate member of the Clinical Research Division at the Hutchinson Center.

The findings will be published in the early online edition of the Proceedings of the National Academy of Sciences the week of Sept. 26. Olson and colleagues studied mice with a single copy of the neuroD2 gene and found they had an impaired ability to form emotional memories and conditioned fear.

"Most of us are familiar with the fact that we can remember things better if those memories are formed at a time when there is a strong emotional impact times when we are frightened, angry or falling in love," he said. "That's called emotional-memory formation. The amygdala is the part of the brain that is responsible for formation of emotional memory."

In the brain's early development, the neuroD2 gene encodes the neuroD2 protein to transform undifferentiated stem cell-like cells into neurons, or brain cells. Under the microscope, certain areas of the amygdala were absent in mice with no neuroD2 gene. In mice with just one copy of neuroD2, researchers also found fewer nerve cells in the amygdala.

Researchers conducted experiments on mice with a single copy of the neuroD2 gene to test the theory that only having one copy of the gene impacts emotional learning and the development of traits such as fear and aggression.
'"/>

Contact: Dean Forbes
dforbes@fhcrc.org
206-667-2896
Fred Hutchinson Cancer Research Center
26-Sep-2005


Page: 1 2 3

Related biology news :

1. Study begins to reveal clues to the cause and progression of sepsis
2. Study finds gender differences in renal and other genes contributing to blood pressure
3. Study suggests estrogen deficiency can lead to obesity-induced high blood pressure after menopause
4. Study: Sticking to the sand might not be such good, clean fun for beachgoers
5. Study points to new way to predict death risk from torn aorta
6. Study identifies new gene therapy tools for inherited blindness
7. Study finds contaminated water reaching Floridas offshore keys
8. Study sheds light on why humans walk on two legs
9. Study explains how pathogens evolve to escape detection
10. Study finds hereditary link to premenstrual depression
11. Study identifies energy efficiency as reason for evolution of upright walking

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/11/2020)... ... May 11, 2020 , ... ... platform for patients with implanted cardiac devices. The Octagos software allows healthcare professionals ... The software greatly simplifies the management of remote transmissions and at the same ...
(Date:5/1/2020)... ... April 30, 2020 , ... Flagship Biosciences ... Consulting Inc., a biopharmaceutical and regulatory services advisor. The companies now deliver regulatory ... and Corritori are taking a collaborative approach to empower more confident and informed ...
(Date:4/30/2020)... ... April 28, 2020 , ... Ever ... latest effort in providing timely and critical information to life science organizations as ... and health safety concerns. , “Providing the most up-to-date actionable guidance and information ...
Breaking Biology News(10 mins):
(Date:5/5/2020)... ... ... ProductLife Group has marked the next phase in its global growth ambitions ... Altran, where he was Group VP of Life Sciences and Head of Life Sciences ... involved in his early career in the development of new medical devices for the ...
(Date:4/22/2020)... ... April 20, 2020 , ... Global molecular diagnostics ... that Omixon’s founder and chairman Dr. Attila Berces returns as CEO. Outgoing CEO ... since 2014 before stepping into the CEO role in 2017. , In ...
(Date:4/7/2020)... ... 06, 2020 , ... Red Nucleus, a leading provider of ... the release of at-home virtual learning resources for all client partners. , “With ... of our employees as we continue to implement measures to safeguard the well-being ...
(Date:4/1/2020)... ... March 31, 2020 , ... Bedoukian ... signing of a Joint Development Agreement that builds on each company’s expertise in ... global leader in the supply of high-quality insect pheromones as well as flavors ...
Breaking Biology Technology:
Cached News: