HOME >> BIOLOGY >> NEWS
Study identifies new gene therapy tools for inherited blindness

" Corbo and colleagues began their studies with three genes previously shown to be important to regulation of photoreceptor proteins. The three genes, known as transcription factors, act by binding to DNA in a way that turns other genes on or off.

"Using a computerized search of DNA, we were able to identify several hundred potential binding sites for these transcription factors," Corbo explains.

Through a variety of experiments, Corbo's group confirmed that 19 of the new sites are involved in regulation of photoreceptor genes linked to inherited forms of blindness. By studying new and previously established sites, they derived some basic rules or "grammar" that seem to govern how the sites work.

"We've by no means finished defining this grammarit's going to be a major task," he explains. "But what we know now has allowed us to create entirely synthetic cis-regulatory elements which function in photoreceptors. A more complete grammar may even one day allow us to design customized versions of cis-regulatory elements to incorporate into gene therapy vectors for individual patients."

In addition to further studies of the grammar of regulatory sites active in photoreceptor cells, Corbo and others are currently using the results of the study to design gene therapy vectors for a form of Leber's congenital amaurosis, an inherited disorder that leaves patients blind from birth.


'"/>

Contact: Michael C. Purdy
purdym@wustl.edu
314-286-0122
Washington University School of Medicine
25-Jul-2007


Page: 1 2

Related biology news :

1. Study begins to reveal clues to the cause and progression of sepsis
2. Study finds gender differences in renal and other genes contributing to blood pressure
3. Study suggests estrogen deficiency can lead to obesity-induced high blood pressure after menopause
4. Study: Sticking to the sand might not be such good, clean fun for beachgoers
5. Study points to new way to predict death risk from torn aorta
6. Study finds contaminated water reaching Floridas offshore keys
7. Study sheds light on why humans walk on two legs
8. Study explains how pathogens evolve to escape detection
9. Study finds hereditary link to premenstrual depression
10. Study identifies energy efficiency as reason for evolution of upright walking
11. Study shows cane sugar, corn sweeteners have similar effects on appetite

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:7/31/2018)... (PRWEB) , ... July 31, 2018 , ... GSL ... connect seamlessly with LabArchives , the leading cloud-based Electronic Lab Notebook (ELN) platform. ... LabArchives enables researchers to store all of their research data records in a secure, ...
(Date:7/28/2018)... ... 2018 , ... Inthirani Arul, an evidence-based healer, today announces research results based ... autoimmune disorders. , Biomarkers for immune function, blood, as well as, inflammation, were ... 110% increase in overall immunity as seen by the rise in antibody levels , ...
(Date:7/26/2018)... ... , ... The Conference Forum has confirmed the agenda for the 5th Annual ... the Marriott Copley Place in Boston, MA. , Daniel Karlin, MD, Head of Experimental ... to lead the discussion on how and when to implement mobile/digital technology in clinical ...
Breaking Biology News(10 mins):
(Date:7/25/2018)... (PRWEB) , ... July 25, 2018 , ... ... a biofield energy treated proprietary nutraceutical to combat inflammation and autoimmune disorders. ... as, immune function response. The following data was reported:, ...
(Date:7/24/2018)... ... 2018 , ... Mark Stutheit, an evidence-based energy healer, today ... improve anti-inflammatory, and immune function responses. , Biomarkers for systemic and organ-specific inflammation, ... reduced. Results are as follows:, , More than 40% ...
(Date:7/22/2018)... ... July 19, 2018 , ... Mitotech S.A, ... Essex Bio-Investment for Phase 3 clinical program in Dry Eye Disease. Under the ... with approximately $17m allocated towards the first Phase 3 study starting as early ...
(Date:10/12/2017)... ... October 12, 2017 , ... They call it ... biological network, a depiction of a system of linkages and connections so complex ... associate professor of computer science at Worcester Polytechnic Institute (WPI) and director of ...
Breaking Biology Technology:
Cached News: