HOME >> BIOLOGY >> NEWS
Study identifies target for preventing sexual transmission of HIV

WASHINGTON -- Researchers have shown that it may be possible to block male to female HIV transmission in heterosexual intercourse and have identified the target for blocking that transmission, according to an article from the Oct. 14 issue of Science, presented today at the American Medical Association 23rd Annual Science Reporters Conference in Washington, D.C.

"Effective methods for blocking the transmission of HIV are urgently needed," said Michael Lederman, M.D., Scott R. Inkley Professor of Medicine and director of the Case Western Reserve University/University Hospitals of Cleveland Center for AIDS Research, in Cleveland, Ohio, and lead author on the paper. "Our study focuses on a strategy for preventing transmission of HIV through the vagina. We have identified a potential target, a mechanism critical for the transmission at vaginal sites of infection, that may offer a simple strategy for preventing HIV transmission."

"The vast majority of HIV infections in the world are sexually transmitted, most commonly through heterosexual sex," Dr. Lederman said. "But there has been substantial debate as to how the virus actually gets into cells at these sites of transmission, called mucosal sites. HIV can use certain cell surface molecules such as CCR5 to gain entry into immune system cells called CD4. We knew that people with a mutation whose CD4 cells' surface lack CCR5 are almost completely protected from acquiring HIV infection."

"But HIV can also use other target molecules to get into other cells. Thus, there was some uncertainty as to how HIV was transmitted at mucosal sites and therefore which pathways needed to be blocked in order to prevent HIV transmission there. We decided to test the hypothesis that blocking CCR5 alone would be sufficient to protect rhesus macaques from vaginal challenge with a virus like HIV. A natural immune messenger (chemokine) called RANTES can bind to CCR5 and by binding, forces the cell to internali
'"/>

Contact: George Stamatis
george.stamatis@case.edu
216-368-3635
American Medical Association
14-Oct-2004


Page: 1 2

Related biology news :

1. Study begins to reveal clues to the cause and progression of sepsis
2. Study finds gender differences in renal and other genes contributing to blood pressure
3. Study suggests estrogen deficiency can lead to obesity-induced high blood pressure after menopause
4. Study: Sticking to the sand might not be such good, clean fun for beachgoers
5. Study points to new way to predict death risk from torn aorta
6. Study identifies new gene therapy tools for inherited blindness
7. Study finds contaminated water reaching Floridas offshore keys
8. Study sheds light on why humans walk on two legs
9. Study explains how pathogens evolve to escape detection
10. Study finds hereditary link to premenstrual depression
11. Study identifies energy efficiency as reason for evolution of upright walking

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/24/2017)... 2017 Janice Kephart , former ... Strategy Partners, LLP (IdSP) , today issues the ... Trump,s March 6, 2017 Executive Order: Protecting ... can be instilled with greater confidence, enabling the ... refugee applications are suspended by until at least ...
(Date:4/13/2017)... According to a new market research report "Consumer ... Administration, and Authorization), Service, Authentication Type, Deployment Mode, Vertical, and Region - ... to grow from USD 14.30 Billion in 2017 to USD 31.75 Billion ... ... MarketsandMarkets Logo ...
(Date:4/6/2017)... LONDON , April 6, 2017 ... Control, RFID, ANPR, Document Readers, by End-Use (Transportation & ... Energy Facility, Oil, Gas & Fossil Generation Facility, Nuclear ... Healthcare, Educational, Other) Are you looking for ... Authentication sector? ...
Breaking Biology News(10 mins):
(Date:6/27/2017)... (PRWEB) , ... June 27, 2017 , ... ... Certification Program (ESTCP), powder activated carbon (PAC)-based materials do not have negative short- ... community at a site contaminated with polychlorinated biphenyls (PCBs) located at the Puget ...
(Date:6/26/2017)... Milwaukee, WI (PRWEB) , ... June 26, 2017 , ... ... today in role of Sales Director, focused on leading new business development and ensuring ... 10 years of experience in the food ingredient industry in technical, marketing and sales ...
(Date:6/23/2017)... ... June 23, 2017 , ... RURO, Inc., a ... of LimitLIS®, its rapidly growing Laboratory Information System. , LimitLIS® version 3 is ... integrity, and provide more customization options. Each of these has been “under the ...
(Date:6/22/2017)... ... June 21, 2017 , ... ... top executive talent in the life sciences industry, today announces a strategic partnership ... The partnership takes full advantage of Beaker’s expertise in executive recruitment solutions, providing ...
Breaking Biology Technology:
Cached News: