Study illuminates birth defects caused by copper deficiency

biochemical processes including cellular respiration, iron oxidation, and the formation of pigments and connective tissue, Gitlin said. The signs and symptoms of copper deficiency therefore result from the impaired function of such copper-containing enzymes.

Considerable clinical and experimental data had suggested that copper is an essential nutrient for normal development, the researchers said. Children with Menkes disease harbor a mutant version of the gene encoding so-called copper-transport ATPase (ATP7A), leading to symptoms including degeneration of parts of the brain and severe failure to thrive. Similarly, in a variety of mammals, copper deficiency during pregnancy results in loss of the embryo or offspring with severe neurologic impairment and developmental defects of the heart, skeleton, and other tissues.

By studying developing zebrafish treated with drugs that interfered with copper metabolism in the current study, the researchers found that copper deficiency led to a loss of pigment and profoundly altered notochord development. Further examination also revealed other impairments, including abnormal cartilage, vascular, and neurologic development, they reported.

Careful examination of embryos treated with different doses of copper-blocking drugs or for different lengths of time uncovered a hierarchy of copper distribution within the developing embryo. For example, a 10 min drug treatment resulted in absence of pigment but a normal notochord. Extending the treatment to 20 min resulted in loss of pigment and a clearly abnormal notochord, and by 60 min, the treatment led to still other defects.

The team then screened mutant zebrafish for defects like those caused by copper deficiency, identifying one with a "striking resemblance--particularly in its lack of melanin pigment and wavy notochord--to the chemically induced copper-deficient" animals. The zebrafish harbored a mutation in the copper transport gene ATP7A tha

Contact: Heidi Hardman
Cell Press

Page: 1 2 3

Related biology news :

1. Study begins to reveal clues to the cause and progression of sepsis
2. Study finds gender differences in renal and other genes contributing to blood pressure
3. Study suggests estrogen deficiency can lead to obesity-induced high blood pressure after menopause
4. Study: Sticking to the sand might not be such good, clean fun for beachgoers
5. Study points to new way to predict death risk from torn aorta
6. Study identifies new gene therapy tools for inherited blindness
7. Study finds contaminated water reaching Floridas offshore keys
8. Study sheds light on why humans walk on two legs
9. Study explains how pathogens evolve to escape detection
10. Study finds hereditary link to premenstrual depression
11. Study identifies energy efficiency as reason for evolution of upright walking

Post Your Comments:

(Date:5/31/2019)... ... , ... Join Julie Peacock, Vice President of Product Marketing ... 19, 2019 at 1pm EDT where she will demonstrate how role-based data solutions ... research organizations (CROs) can improve collaboration, auditing, document tracking and reporting. , Using ...
(Date:5/23/2019)... ... May 23, 2019 , ... Federal Publications Seminars, the leading provider ... to announce the release of FPSOnline 2.0, an updated version of its FPSOnline ... conferences , La Jolla Government Contracts Week, were given a “sneak peek” of FPSOnline ...
(Date:5/21/2019)... ... May 21, 2019 , ... Experiential tourism, a trend encompassing ... over the last several years. And according to a recent report by Skift, ... In fact, more and more travelers are wanting their journeys to be authentic ...
Breaking Biology News(10 mins):
(Date:5/31/2019)... ... May 30, 2019 , ... Object Pharma, ... the strategic acquisition of Metabiologics, Inc., a globally recognized leader in the production ... and commercialization rights to a full spectrum of botulinum neurotoxins, as well as ...
(Date:5/22/2019)... NEW YORK (PRWEB) , ... May 22, 2019 , ... ... it has closed a $8 million Series A funding round co-led by Astanor ... State’s Empire State Development Fund and iSelect Fund . The company ...
(Date:5/15/2019)... ... , ... Milton Hershey School® has named William Charles Ballough Harding ’78 the ... where he is changing lives by creating solutions to global healthcare challenges through the ... of our founders – Milton and Catherine Hershey – who always hoped for Milton ...
(Date:5/14/2019)... ... May 13, 2019 , ... Leak Detection Associates (LDA), the ... Biotechnology, Medical Device and Food Packaging Industries’ is excited to announce the go-live ... LDA’s ability to communicate directly with the marketplace; serving as a destination to ...
Breaking Biology Technology:
Cached News: