Study implicates potassium channel mutations in neurodegeneration and mental r...( f excitotoxicity (overstimulation). Th...)

f excitotoxicity (overstimulation). The altered potassium channels might prevent neurons from coping well with oxidative stress damage from reactive molecules called free radicals that are produced during metabolism. The mutations also might cause subtle developmental defects that reduce the long-term survival of neurons, the researchers say.

The new findings suggest that spinocerebellar ataxia and other neurodegenerative diseases might be treatable with drugs that alter the activity of potassium channels. To maximize the benefits and reduce side effects, researchers would need to find drugs that are specific for this type of channel, Dr. Pulst says.

The investigators now plan to use cell cultures and animal models to help them learn exactly how the mutations cause neurodegeneration. These studies could lead to improved treatments for a number of diseases.

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Contact: Natalie Frazin or Paul Girolami
301-496-5924
NIH/National Institute of Neurological Disorders and Stroke
26-Feb-2006

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