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Study links ADHD cognitive and behavioral problems to genetic and environmental interactions

tional flexibility.

"In addition, increasing lead exposure impaired performance in both planning and attentional flexibility in boys more than in girls. This suggests that, for these executive functions, boys are more vulnerable to the adverse affects of lead exposure," says Dr. Froehlich. "This is also consistent with the established fact that boys have higher rates of ADHD than girls."

The researchers studied 172 children who were enrolled in a community-based study of low levels of lead exposure. Blood lead levels were assessed during infancy and early childhood. At age 5, children took standardized, ADHD-related executive function tests.

"This study offers a model for examining how genes and environmental toxins interact to shape ADHD, and demonstrates that important effects may be obscured or over-generalized if the joint contributions of these factors are not considered," says Dr. Froehlich. "Such studies can help us understand the underlying causes of neuropsychological disorders, and why certain groups may be more prone to ADHD than others."


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Contact: Jim Feuer
jim.feuer@cchmc.org
513-636-4656
Cincinnati Children's Hospital Medical Center
1-May-2006


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