Study reveals trigger for insulin resistance in liver, potential drug targets

In the July issue of Cell Metabolism, researchers report the discovery of a trigger for insulin resistance in the liver. Hepatic insulin resistance is a silent condition that increases the chances of developing diabetes and heart disease. The team's findings also identify a potential target for drugs to prevent or treat the condition, the researchers said.

The livers of mice lacking an enzyme called mitochondrial acyl-CoA:glycerol-sn-3-phosphate acyltransferase 1 (mtGPAT1) remain sensitive to insulin's effects when fed a high-fat diet. The mice also exhibit lower concentrations of a lipid metabolite that might play a key role in triggering the liver to become insulin resistant, the researchers found.

Along with the existing epidemic of obesity, fatty liver, also known as hepatic steatosis, is rapidly becoming a major health care problem, said Howard Hughes Medical Institute investigator Gerald Shulman of Yale University, senior author of the study. Fatty liver can lead to altered liver function, elevated lipids such as cholesterol and triglycerides in the bloodstream, and progression to liver cirrhosis, he said. Characterized by scarring, cirrhosis of the liver is the twelfth leading cause of death by disease, according to the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK).

Furthermore, Shulman added, recent studies have demonstrated an important role of hepatic steatosis in causing insulin resistance in the liver, resulting in increased liver production of glucose, and high blood sugar in patients with type 2 diabetes.

"Through noninvasive measurements of hepatic triglyceride content in humans, we've learned that elevated liver fat is fairly ubiquitous in patients with poorly controlled type 2 diabetes," Shulman said. "It's been an underappreciated aspect of the disease."

The researchers examined whether or not mice deficient for the mtGPAT1 enzyme would be protected from fatty liver and liver insu

Contact: Heidi Hardman
Cell Press

Page: 1 2

Related biology news :

1. Study begins to reveal clues to the cause and progression of sepsis
2. Study finds gender differences in renal and other genes contributing to blood pressure
3. Study suggests estrogen deficiency can lead to obesity-induced high blood pressure after menopause
4. Study: Sticking to the sand might not be such good, clean fun for beachgoers
5. Study points to new way to predict death risk from torn aorta
6. Study identifies new gene therapy tools for inherited blindness
7. Study finds contaminated water reaching Floridas offshore keys
8. Study sheds light on why humans walk on two legs
9. Study explains how pathogens evolve to escape detection
10. Study finds hereditary link to premenstrual depression
11. Study identifies energy efficiency as reason for evolution of upright walking

Post Your Comments:

(Date:8/21/2020)... ... August 19, 2020 , ... “How can we help?”, ... to Salivary Bioscience for more than twenty years. Together with Douglas Granger, Ph.D., ... Salivary Bioscience: Foundations of Interdisciplinary Saliva Research and Applications ," and Steven Granger, ...
(Date:8/12/2020)... ... August 12, 2020 , ... ... systems that are ideal for public health agencies of all sizes. With a ... and helping at-risk individuals find appropriate health care, Mosio helps public health departments ...
(Date:8/3/2020)... , ... August 03, 2020 , ... ... announced a new partnership with medical equipment manufacturer, Spectrum Solutions, to provide COVID-19 ... to strengthen their laboratory supply chain for more than 10 years. Early in ...
Breaking Biology News(10 mins):
(Date:8/31/2020)... ... 2020 , ... DuPont Nutrition & Biosciences announced today the ... plant operation will provide the local animal production industry with customized solutions according ... improve the flexibility of our offerings to the Chinese animal nutrition market,” said ...
(Date:8/12/2020)... ... August 11, 2020 , ... ... engineering firm, is making available for free its new white paper – ... transport simulation testing into today’s biologics licensing application (BLA). In response, Modality ...
(Date:8/3/2020)... ... August 03, 2020 , ... Introducing Ardent Animal Health – MediVet ... , Known as MediVet Biologics since its formation in 2016, the ... new Ardent Animal Health will build on its base of innovative therapies for osteoarthritis ...
(Date:7/31/2020)... ... July 29, 2020 , ... ... combine up to three different materials for use with CRM, neurostimulation, vascular, and ... three materials to meet specific design requirements, performance, and cost criteria; especially where ...
Breaking Biology Technology:
Cached News: