HOME >> BIOLOGY >> NEWS
Study shows frogs can play key role in stem cell research

It sounds like one of those curiosities which pops up in wildlife documentaries, but the African clawed frog could prove a powerful ally for scientists working in the key area of stem cell research. Researchers at the University of Edinburgh have discovered that the distinctive species which has become popular in recent years as a domestic pet shares with humans the same genetic mechanism that enables embryonic stem cells to divide without limit. This process, which gives embryonic stem cells the capacity to become any of the 200 cell types in the body, is fundamental to all research in the discipline.

Until now, stem cells have been obtained from mice, primates and humans, but never from amphibians. But, because the African clawed frog is easier to study than mice and humans, the Edinburgh team anticipate that it will become an important research tool in their quest to understand and, ultimately, treat disease using stem cells. The results of their study are published in the current edition of the journal Development.

The key protein in humans, called Oct4, which governs the process of unlimited division of stem cells, has an equivalent in the African clawed frog, called PouV. This new research shows that the two proteins are not only similar, but perform the same function both bind to DNA and activate certain genes that keep stem cells dividing. Indeed, embryonic stem cells lacking the Oct4 protein stop dividing and become specialised.

In the study, Dr Gillian Morrison introduced frog PouV proteins into mouse embryonic stem cells lacking Oct4 and found that the frog proteins "rescued" the stem cells in other words, the cells recovered their ability to divide without limit. Dr Morrison obtained similar effects when she introduced PouV proteins from another amphibian, the axolotl (a type of salamander).

To find out exactly what function PouV proteins perform in frog embryos, Dr Morrison injected special compounds into very young
'"/>

Contact: Ana Coutinho
ana.coutinho@ed.ac.uk
44-131-650-5830
University of Edinburgh
14-May-2006


Page: 1 2

Related biology news :

1. Study begins to reveal clues to the cause and progression of sepsis
2. Study finds gender differences in renal and other genes contributing to blood pressure
3. Study suggests estrogen deficiency can lead to obesity-induced high blood pressure after menopause
4. Study: Sticking to the sand might not be such good, clean fun for beachgoers
5. Study points to new way to predict death risk from torn aorta
6. Study identifies new gene therapy tools for inherited blindness
7. Study finds contaminated water reaching Floridas offshore keys
8. Study sheds light on why humans walk on two legs
9. Study explains how pathogens evolve to escape detection
10. Study finds hereditary link to premenstrual depression
11. Study identifies energy efficiency as reason for evolution of upright walking

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Study shows frogs can play key role stem cell research

(Date:7/31/2014)... Census Bureau, Latinos are the largest minority group in ... Approximately one-third of Latinos are obese and are 1.2 ... Whites. , NYU College of Nursing student researcher ... identify the factors that contribute to this problem by ... on food patterns in Latina women recently published in ...
(Date:7/31/2014)... beneath many of the roughly 156,000 gas stations ... corrosion in parts of underground gas storage tankscorrosion ... of groundwater, a source of drinking water. In ... reported many rapidly corroding gas storage tank components ... associated with use of gasoline-ethanol blends and the ...
(Date:7/31/2014)... experimental vaccine protected 100 percent of animal models against ... , which causes an intestinal disease that kills approximately ... print in Infection and Immunity . , ... non-human primates against the purified toxins produced by ... spore infection, a laboratory model that mimics the human ...
Breaking Biology News(10 mins):NYU research looks to combat US Latina immigrant obesity 2NIST corrosion lab tests suggest need for underground gas tank retrofits 2C. difficile vaccine proves safe, 100 percent effective in animal models 2
(Date:7/31/2014)... “2014 Deep Research Report ... is a professional and in-depth research report ... Polyurethane Resin basic information, including its definition, ... industry overview. This research covers the international ... well as global industry analysis covering macroeconomic ...
(Date:7/31/2014)... even the entire body to visualize long-range connections between ... a long-time dream of biologists. A study published by ... Cell has now made that dream a ... and human tissue biopsies transparent, while keeping the cellular ... way for a better understanding of brain-body interactions, more ...
(Date:7/31/2014)... , July 31, 2014 Rogne Bioscience, a ... Bay Area , has acquired a licence to ... commercialisation company. The potent anti-inflammatory activity of the peptides ... the University of Oxford,s Sir William Dunn School ... has raised over $1.5 million in seed financing, is ...
(Date:7/31/2014)... San Francisco, California (PRWEB) July 31, 2014 ... expert systems that inform therapeutic decision-making in oncology, today ... on August 14, 2014 to discuss the Company's financial ... to provide an update about the business in the ... live audio call beginning on Thursday, August 14, 2014, ...
Breaking Biology Technology:Polyurethane Resin Industry & Thermoplastic Polyurethane Market (China, Global) Analysis Now at DeepResearchReports.com 2Polyurethane Resin Industry & Thermoplastic Polyurethane Market (China, Global) Analysis Now at DeepResearchReports.com 3Polyurethane Resin Industry & Thermoplastic Polyurethane Market (China, Global) Analysis Now at DeepResearchReports.com 4See-through organs and bodies will accelerate biomedical discoveries 2Oxford licenses anti-inflammatory peptides to San Francisco Bay Area start-up 2Oxford licenses anti-inflammatory peptides to San Francisco Bay Area start-up 3CollabRx, Inc. Schedules First Quarter Fiscal Year 2015 Financial Conference Call and Business Update 2
Cached News: