HOME >> BIOLOGY >> NEWS
Study shows frogs can play key role in stem cell research

It sounds like one of those curiosities which pops up in wildlife documentaries, but the African clawed frog could prove a powerful ally for scientists working in the key area of stem cell research. Researchers at the University of Edinburgh have discovered that the distinctive species which has become popular in recent years as a domestic pet shares with humans the same genetic mechanism that enables embryonic stem cells to divide without limit. This process, which gives embryonic stem cells the capacity to become any of the 200 cell types in the body, is fundamental to all research in the discipline.

Until now, stem cells have been obtained from mice, primates and humans, but never from amphibians. But, because the African clawed frog is easier to study than mice and humans, the Edinburgh team anticipate that it will become an important research tool in their quest to understand and, ultimately, treat disease using stem cells. The results of their study are published in the current edition of the journal Development.

The key protein in humans, called Oct4, which governs the process of unlimited division of stem cells, has an equivalent in the African clawed frog, called PouV. This new research shows that the two proteins are not only similar, but perform the same function both bind to DNA and activate certain genes that keep stem cells dividing. Indeed, embryonic stem cells lacking the Oct4 protein stop dividing and become specialised.

In the study, Dr Gillian Morrison introduced frog PouV proteins into mouse embryonic stem cells lacking Oct4 and found that the frog proteins "rescued" the stem cells in other words, the cells recovered their ability to divide without limit. Dr Morrison obtained similar effects when she introduced PouV proteins from another amphibian, the axolotl (a type of salamander).

To find out exactly what function PouV proteins perform in frog embryos, Dr Morrison injected special compounds into very young
'"/>

Contact: Ana Coutinho
ana.coutinho@ed.ac.uk
44-131-650-5830
University of Edinburgh
14-May-2006


Page: 1 2

Related biology news :

1. Study begins to reveal clues to the cause and progression of sepsis
2. Study finds gender differences in renal and other genes contributing to blood pressure
3. Study suggests estrogen deficiency can lead to obesity-induced high blood pressure after menopause
4. Study: Sticking to the sand might not be such good, clean fun for beachgoers
5. Study points to new way to predict death risk from torn aorta
6. Study identifies new gene therapy tools for inherited blindness
7. Study finds contaminated water reaching Floridas offshore keys
8. Study sheds light on why humans walk on two legs
9. Study explains how pathogens evolve to escape detection
10. Study finds hereditary link to premenstrual depression
11. Study identifies energy efficiency as reason for evolution of upright walking

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Study shows frogs can play key role stem cell research

(Date:3/17/2015)... , March 17, 2015 Emotient, ... analytics software, today announced general availability of ... service for the analysis of facial expressions. The ... advertising, media content, products and services. It delivers ... engagement and sentiment - as derived from facial ...
(Date:3/16/2015)... 2015 Between 16 and ... groundbreaking innovations in biometric identification at the CeBIT ...      (Photo: http://photos.prnewswire.com/prnh/20150316/735333 ) ... well at the forefront: the company,s all new ... Germany . BiometricGate is the ...
(Date:3/12/2015)... N.C. , March 12, 2015 The ... at Brenner Children,s Hospital, part of Wake Forest Baptist ... outreach initiative for the 2015 ACC Men,s Basketball Tournament. ... pictures with them and getting their autographs. ... Forest Baptist. It is the only children,s hospital in ...
Breaking Biology News(10 mins):New Emotient Web Service Measures Audience Response Using On-Demand Facial Expression Analysis 2New Emotient Web Service Measures Audience Response Using On-Demand Facial Expression Analysis 3New Emotient Web Service Measures Audience Response Using On-Demand Facial Expression Analysis 4DERMALOG Presents its Latest Biometric Innovations at the Hannover CeBIT Exhibition, 16 - 20 March 2015 2DERMALOG Presents its Latest Biometric Innovations at the Hannover CeBIT Exhibition, 16 - 20 March 2015 3
(Date:3/27/2015)... , 27. März 2015  Peter ... in Biomedical Science für seine bahnbrechende Arbeit ... zwischen Zellkompartimenten transportiert werden, sowie für die ... zur Reaktion auf Stress nutzen, der mit ... Walter ist Professor für Biochemie an der ...
(Date:3/27/2015)... 27, 2015 Working in collaboration with ... London , Richmond Pharmacology is the first ... 3 study for an investigational RNAi therapeutic being developed for ... the nerves and heart. Read press release ... Based at St Georges University of London ...
(Date:3/26/2015)... Bioscience, Inc. (NASDAQ: ROKA ), a molecular ... for the detection of foodborne pathogens, today reported ... full year ended December 31, 2014. ... ended December 31, 2014 was $1.4 million compared ... and $1.5 million for the third quarter of ...
(Date:3/26/2015)... , March 26, 2015  BioNano Genomics, Inc., ... of  Terry Salyer as chief commercial officer. Salyer ... effective, worldwide sales teams in life sciences. At BioNano, ... System, a genome-mapping platform to assemble a comprehensive ... structural variations. To date, 32 institutions located in ...
Breaking Biology Technology:Deutschstämmiger Zellbiologe Peter Walter gewinnt den Vilcek Prize in Biomedical Science 2015 2Deutschstämmiger Zellbiologe Peter Walter gewinnt den Vilcek Prize in Biomedical Science 2015 3Deutschstämmiger Zellbiologe Peter Walter gewinnt den Vilcek Prize in Biomedical Science 2015 4Roka Bioscience Reports Fourth Quarter and Full Year 2014 Financial Results 2Roka Bioscience Reports Fourth Quarter and Full Year 2014 Financial Results 3Roka Bioscience Reports Fourth Quarter and Full Year 2014 Financial Results 4Roka Bioscience Reports Fourth Quarter and Full Year 2014 Financial Results 5Roka Bioscience Reports Fourth Quarter and Full Year 2014 Financial Results 6Roka Bioscience Reports Fourth Quarter and Full Year 2014 Financial Results 7BioNano Genomics Appoints Terry Salyer as Chief Commercial Officer 2BioNano Genomics Appoints Terry Salyer as Chief Commercial Officer 3
Cached News: