HOME >> BIOLOGY >> NEWS
Study shows frogs can play key role in stem cell research

It sounds like one of those curiosities which pops up in wildlife documentaries, but the African clawed frog could prove a powerful ally for scientists working in the key area of stem cell research. Researchers at the University of Edinburgh have discovered that the distinctive species which has become popular in recent years as a domestic pet shares with humans the same genetic mechanism that enables embryonic stem cells to divide without limit. This process, which gives embryonic stem cells the capacity to become any of the 200 cell types in the body, is fundamental to all research in the discipline.

Until now, stem cells have been obtained from mice, primates and humans, but never from amphibians. But, because the African clawed frog is easier to study than mice and humans, the Edinburgh team anticipate that it will become an important research tool in their quest to understand and, ultimately, treat disease using stem cells. The results of their study are published in the current edition of the journal Development.

The key protein in humans, called Oct4, which governs the process of unlimited division of stem cells, has an equivalent in the African clawed frog, called PouV. This new research shows that the two proteins are not only similar, but perform the same function both bind to DNA and activate certain genes that keep stem cells dividing. Indeed, embryonic stem cells lacking the Oct4 protein stop dividing and become specialised.

In the study, Dr Gillian Morrison introduced frog PouV proteins into mouse embryonic stem cells lacking Oct4 and found that the frog proteins "rescued" the stem cells in other words, the cells recovered their ability to divide without limit. Dr Morrison obtained similar effects when she introduced PouV proteins from another amphibian, the axolotl (a type of salamander).

To find out exactly what function PouV proteins perform in frog embryos, Dr Morrison injected special compounds into very young
'"/>

Contact: Ana Coutinho
ana.coutinho@ed.ac.uk
44-131-650-5830
University of Edinburgh
14-May-2006


Page: 1 2

Related biology news :

1. Study begins to reveal clues to the cause and progression of sepsis
2. Study finds gender differences in renal and other genes contributing to blood pressure
3. Study suggests estrogen deficiency can lead to obesity-induced high blood pressure after menopause
4. Study: Sticking to the sand might not be such good, clean fun for beachgoers
5. Study points to new way to predict death risk from torn aorta
6. Study identifies new gene therapy tools for inherited blindness
7. Study finds contaminated water reaching Floridas offshore keys
8. Study sheds light on why humans walk on two legs
9. Study explains how pathogens evolve to escape detection
10. Study finds hereditary link to premenstrual depression
11. Study identifies energy efficiency as reason for evolution of upright walking

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:12/20/2016)... and GENEVA, Dec, 20, 2016   Valencell ... sensor technology, and STMicroelectronics (NYSE: STM), a ... of electronics applications, announced today the launch of ... for biometric wearables that includes ST,s compact ... Valencell,s Benchmark™ biometric sensor system. Together, SensorTile ...
(Date:12/16/2016)... Research and Markets has announced the addition of the "Biometric ... to their offering. ... The biometric vehicle access system market, in terms of value, ... to 2021. The market is estimated to be USD 442.7 Million ... The growth of the biometric vehicle access system market is fueled ...
(Date:12/15/2016)... Calif. , Dec. 15, 2016   WaferGen ... publicly held genomics technology company, announced today that on ... Listing Qualifications Department of The Nasdaq Stock Market LLC ... closing bid price of WaferGen,s common stock had been ... Accordingly, WaferGen has regained compliance with Listing Rule 5550(a)(2) ...
Breaking Biology News(10 mins):
(Date:1/12/2017)... ... January 12, 2017 , ... After her brain cancer ... gave her only a few months to live. Now a paper publishing January ... Rosendahl’s disease and increased both the quantity and quality of her life: Adding ...
(Date:1/12/2017)... and Pune, India , January 12, 2017 ... Market by Type and End Users - Global Opportunity Analysis and Industry Forecast, 2014-2022," ... 2022 from $2,921 million in 2015, growing at a CAGR of 15.07% during the ... ... Allied Market Research Logo ...
(Date:1/11/2017)... ... January 11, 2017 , ... Phase 1 clinical trial ... of the investigational anti-cancer agent tucatinib (formerly ONT-380) against HER2+ breast cancer. The ... percent of these heavily pretreated patients saw clinical benefit from the drug, with ...
(Date:1/11/2017)... ... January 11, 2017 , ... Photonics industry and STEM ... are commending the U.S. Congress and President Obama for their recognition of the ... the American Innovation and Competitiveness Act (AICA). , The language of the act ...
Breaking Biology Technology:
Cached News: