HOME >> BIOLOGY >> NEWS
Study shows how protein raises antibody output

Columbus , Ohio Cancer immunologists here have discovered how a protein on the surface of antibody-making immune cells boosts the amount of antibody the cells make.

The protein, called CD86, is present on B lymphocytes, or B cells, which make infection-fighting antibodies.

Researchers have long known that B cells use the protein to stimulate other immune cells known as T lymphocytes, or T cells, when the two have contact early in an immune response. But the protein was thought to cause no change in the B-cell itself during that interaction.

The study by Ohio State University scientists is published in a recent issue of The Journal of Immunology.

The research, conducted in mouse cells, provides important details about how B cells make antibodies in response to infections. Antibodies are proteins that attach to viruses, bacteria and other infectious agents to disable them.

The findings could lead to new ways of boosting the immune response against bacteria that cause pneumonia, a leading killer of people with weakened immunity such as cancer and HIV/AIDS, and of controlling autoimmune diseases.

"Our findings describe a previously unknown signaling pathway in B cells that helps regulate antibody production," says principal investigator Virginia M. Sanders, professor in department of molecular virology, immunology and medical genetics and an OSU Comprehensive Cancer Center researcher.

"The findings show that CD86 actually sends signals into the B cell itself, causing it to make a greater amount of antibody. If this is verified in human cells, they could be clinically important."

B cells begin making antibodies after they detect bits of bacteria, viruses or cancer cells in the body. But first the cells must be activated by contact with T cells in lymph nodes. During that interaction, CD86 proteins on the B cells fit like a key into a protein on the T cells called CD28.


'"/>

Contact: Darrell E. Ward
Darrell.Ward@osumc.ed
614-293-3737
Ohio State University
2-Aug-2006


Page: 1 2

Related biology news :

1. Study begins to reveal clues to the cause and progression of sepsis
2. Study finds gender differences in renal and other genes contributing to blood pressure
3. Study suggests estrogen deficiency can lead to obesity-induced high blood pressure after menopause
4. Study: Sticking to the sand might not be such good, clean fun for beachgoers
5. Study points to new way to predict death risk from torn aorta
6. Study identifies new gene therapy tools for inherited blindness
7. Study finds contaminated water reaching Floridas offshore keys
8. Study sheds light on why humans walk on two legs
9. Study explains how pathogens evolve to escape detection
10. Study finds hereditary link to premenstrual depression
11. Study identifies energy efficiency as reason for evolution of upright walking

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/20/2017)... ALLENTOWN, Pa. , March 20, 2017 ... PD 2.0 personal spirometer and Wellness Management System (WMS), ... Founded in 2010, PMD Healthcare is a ... Company with a mission dedicated to creating innovative solutions ... of life. With that intent focus, PMD developed the ...
(Date:3/9/2017)... MOUNTAIN VIEW, Calif. , March 9, 2017 /PRNewswire/ ... 23andMe , the leading personal genetics company, are ... can now provide customers with personalized nutrition plans that ... biometrics, but also genetic markers impacting how their body ... personalized food decision support platform uses biometrics such as ...
(Date:3/2/2017)... -- Summary This report provides all the information ... and activities since 2010. ... Read the full report: http://www.reportlinker.com/p03605615-summary/view-report.html ... provides an in-depth insight into the partnering activity of one ... demand company reports are prepared upon purchase to ensure inclusion ...
Breaking Biology News(10 mins):
(Date:3/22/2017)... , March 22, 2017 Oramed Pharmaceuticals ... www.oramed.com ), a clinical-stage ... drug delivery systems, announced today that Dr. ... deliver a presentation titled, "Oral Insulin for Diabetes ... Cambridge Healthtech Institute,s Oligonucleotide and Peptide Therapeutics (OPT) Boston Conference ...
(Date:3/22/2017)... ALBANY, New York , March 22, 2017 /PRNewswire/ ... market is largely fragmented, states a research report by ... Sanofi S.A., Pfizer Inc., Amgen Inc., and AbbVie Inc., ... market in 2015. The prominent players in this market ... to expand their product portfolio, which is likely to ...
(Date:3/22/2017)... , March 22, 2017 /PRNewswire/ - FACIT announced ... "Company" or "Propellon"), a start-up created by FACIT ... therapeutics. FACIT,s investment, combined with non-dilutive capital, achieves ... The seed funding enables Propellon to accelerate the ... Company for financing and/or entering a strategic partnership ...
(Date:3/22/2017)... 2017   VWR (NASDAQ: VWR), ... and service solutions to laboratory and production ... EPL Archives, Inc., an international biorepository services ... regulated product research, development and commercialization lifecycle ... ancillary services. EPL Archives is widely recognized ...
Breaking Biology Technology:
Cached News: