HOME >> BIOLOGY >> NEWS
Study shows metabolic strategy of stressed cell

jude.org/media/0,2561,453_5715_21400,00.html).

In the present study, the St. Jude team showed that low levels of CoA trigger the activation of genes that block other biochemical pathways that ordinarily use this molecule. Instead, the cell shifts most of the available CoA activity to producing glucose from the liver. Other organs then break down glucose into a molecule called pyruvate inside structures called mitochondria. In the mitochondria, CoA molecules perform another job: feeding pyruvate into a complex series of chemical reactions that produces molecules of ATP.

"Our results identify the re-arrangements that the cell's metabolism undergoes in order to ensure that the liver keeps CoA levels high enough to produce glucose and the cells of the body maintain enough free CoA for the mitochondria to keep producing ATP," said Yong-Mei Zhang, Ph.D., of the St. Jude Infectious Diseases department and first author of the report.

The investigators demonstrated many of the metabolic changes caused by a shortage of CoA by treating mice with HoPan. The resulting decrease in CoA triggered severe hypoglycemiaa low level of glucose in the blood. Prior to the hypoglycemia, the liver cells adjusted their metabolism in an effort to maintain the glucose output. This study identified several key steps, including a substantial increase in the amount of enzymes that free CoA from molecules called acyl groups, as well as increases in the amount of acylcarnitine, a molecule that grabs those acyl groups, ensuring that CoA remains free and available for energy production.


'"/>

Contact: Summer Freeman
summer.freeman@stjude.org
901-495-3061
St. Jude Children's Research Hospital
23-Mar-2007


Page: 1 2 3

Related biology news :

1. Study begins to reveal clues to the cause and progression of sepsis
2. Study finds gender differences in renal and other genes contributing to blood pressure
3. Study suggests estrogen deficiency can lead to obesity-induced high blood pressure after menopause
4. Study: Sticking to the sand might not be such good, clean fun for beachgoers
5. Study points to new way to predict death risk from torn aorta
6. Study identifies new gene therapy tools for inherited blindness
7. Study finds contaminated water reaching Floridas offshore keys
8. Study sheds light on why humans walk on two legs
9. Study explains how pathogens evolve to escape detection
10. Study finds hereditary link to premenstrual depression
11. Study identifies energy efficiency as reason for evolution of upright walking

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/1/2016)... smart wallet ( www.wocketwallet.com ) announces the launch of a new video ... Las Vegas , where Joey appeared at the Wocket ... Vegas , where Joey appeared at the Wocket booth to meet ... filmed at the Consumer Electronics Show (CES2016) in Las Vegas ... greet fans. --> --> The ...
(Date:1/25/2016)... -- Glencoe Software, the world-leading supplier of image data management ... the data management solution OMERO Plus for the newly ... Photo - http://photos.prnewswire.com/prnh/20160125/325328LOGO ... Phenotypic analysis measures the characteristics and behavior of cells, ... such as health and disease, the presence or absence ...
(Date:1/20/2016)... LONDON , Jan. 20, 2016 A ... positioned to directly benefit from the explosion in genomics ... from Howe Sound Research. A range of dynamic trends ... ...... - personalized medicine - pharmacogenomics - pathogen ... economies with large markets - greater understanding of the ...
Breaking Biology News(10 mins):
(Date:2/9/2016)... , February 9, 2016 Three-Year Initiative ... Children to Take Part in Life-Changing Camp ... initiative designed to positively affect the lives of children born with ... --> SHPG ) is announcing a new initiative designed ... as well as the future of rare disease care. --> ...
(Date:2/8/2016)... BIOREM Inc. (TSXV: BRM) ("Biorem" or "the Company") today announced ... companies in the TSX Venture 50 TM . ... TSX Venture Exchange, in each of five major industry sectors ... life sciences, diversified industries and technology – based on a ... market cap growth, trading volume and analyst coverage. All data ...
(Date:2/8/2016)... DELHI , February 8, 2016 ... Invictus Oncology Private Limited, an innovation-driven oncology company ... effective and less toxic, today announced that chairman ... Tata, has invested in the company as part ... financing round, joining existing investors Navam Capital and ...
(Date:2/8/2016)... Feb. 8, 2016  BioElectronics Corporation (OTC Pink: ... announced today that it is responding to a ... the Securities and Exchange Commission posted on the ... Chairman of the Board of BioElectronics Corporation and ... Administration at The Fuqua School of Business, Duke ...
Breaking Biology Technology:
Cached News: