HOME >> BIOLOGY >> NEWS
Study shows metabolic strategy of stressed cell

jude.org/media/0,2561,453_5715_21400,00.html).

In the present study, the St. Jude team showed that low levels of CoA trigger the activation of genes that block other biochemical pathways that ordinarily use this molecule. Instead, the cell shifts most of the available CoA activity to producing glucose from the liver. Other organs then break down glucose into a molecule called pyruvate inside structures called mitochondria. In the mitochondria, CoA molecules perform another job: feeding pyruvate into a complex series of chemical reactions that produces molecules of ATP.

"Our results identify the re-arrangements that the cell's metabolism undergoes in order to ensure that the liver keeps CoA levels high enough to produce glucose and the cells of the body maintain enough free CoA for the mitochondria to keep producing ATP," said Yong-Mei Zhang, Ph.D., of the St. Jude Infectious Diseases department and first author of the report.

The investigators demonstrated many of the metabolic changes caused by a shortage of CoA by treating mice with HoPan. The resulting decrease in CoA triggered severe hypoglycemiaa low level of glucose in the blood. Prior to the hypoglycemia, the liver cells adjusted their metabolism in an effort to maintain the glucose output. This study identified several key steps, including a substantial increase in the amount of enzymes that free CoA from molecules called acyl groups, as well as increases in the amount of acylcarnitine, a molecule that grabs those acyl groups, ensuring that CoA remains free and available for energy production.


'"/>

Contact: Summer Freeman
summer.freeman@stjude.org
901-495-3061
St. Jude Children's Research Hospital
23-Mar-2007


Page: 1 2 3

Related biology news :

1. Study begins to reveal clues to the cause and progression of sepsis
2. Study finds gender differences in renal and other genes contributing to blood pressure
3. Study suggests estrogen deficiency can lead to obesity-induced high blood pressure after menopause
4. Study: Sticking to the sand might not be such good, clean fun for beachgoers
5. Study points to new way to predict death risk from torn aorta
6. Study identifies new gene therapy tools for inherited blindness
7. Study finds contaminated water reaching Floridas offshore keys
8. Study sheds light on why humans walk on two legs
9. Study explains how pathogens evolve to escape detection
10. Study finds hereditary link to premenstrual depression
11. Study identifies energy efficiency as reason for evolution of upright walking

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Study shows metabolic strategy stressed cell

(Date:4/17/2014)... KAN. A Kansas State University engineer has ... and remotely detects improvised explosive devices. The same ... William Dunn, the Steven M. and Kay L. ... mechanical and nuclear engineering, and his research team ... hidden underground or in car trunks. The distance ...
(Date:4/17/2014)... Europe, Asia and the United States are spreading across ... native honeybee populations at this time, according to an ... Nosema microsporidia and Varroa mites., ... these invasive pests, which suggests to us that the ... the United States currently are not necessary in East ...
(Date:4/17/2014)... Cell Press journal Current Biology on April ... sex lives. The Brazilian insects, which represent four distinct ... are the first example of an animal with sex-reversed ... in several different animals, Neotrogla is the ... reversed," says Kazunori Yoshizawa from Hokkaido University in Japan. ...
Breaking Biology News(10 mins):Patented research remotely detects nitrogen-rich explosives 2East African honeybees are safe from invasive pests… for now 2East African honeybees are safe from invasive pests… for now 3In sex-reversed cave insects, females have the penises 2
(Date:1/15/2014)... 2014 Look inside the new Preferred ... the lab, from fluid handling to instruments to supplies. ... when you order. , Preferred Solutions features a ... the L/S® model for precise flow control and dispensing ...
(Date:1/15/2014)... 15, 2014 ­ RedBrick Health , a fast-growing ... today announces that EmblemHealth , the ... is now providing the RedBrick Compass health assessment, combined ... all of its members. EmblemHealth is among the first ...
(Date:1/15/2014)... (PRWEB) January 15, 2014 More than ... and about 1 in 3 seniors will die with ... ). These jaw-dropping figures have shocked many Americans into ... hopefully, help prevent these tragic age-related cognitive disorders. Jonathan ...
(Date:1/15/2014)... DTS Language Services, Inc . is ... for Life Science organizations who need document translations. Clients ... of their documents in advance with a selection of nearly ... translations, often a critical factor in clinical and scientific fields, ...
Breaking Biology Technology:Cole-Parmer Begins 2014 with the Release of Preferred Solutions 2EmblemHealth Selects RedBrick Health to Power its Next-Generation Health Engagement and Behavior Change System 2EmblemHealth Selects RedBrick Health to Power its Next-Generation Health Engagement and Behavior Change System 3Biohack Pure Offers 5 Tips for Increasing Memory in 2014 2DTS Improves Efficiency for Life Science Document Translations 2
Cached News: