HOME >> BIOLOGY >> NEWS
Study suggests way to re-energize immune response to chronic viral infection

Like boxers wearied by a 15-round bout, the immune system's CD8 T cells eventually become "exhausted" in their battle against persistent viral infection, and less effective in fighting the disease.

In a study to be published Dec. 28 on the journal Nature's website, researchers at Dana-Farber Cancer Institute and Emory University have traced the problem to a gene that turns off the infection-fighting drive of CD8 T cells in mice. The discovery raises the possibility that CD8 cell exhaustion can be reversed in human patients, reinvigorating the immune system's defenses against chronic viral infections ranging from hepatitis to HIV, the virus that causes AIDS.

"CD8 T cells that have fought viral infections retain a 'memory' of the viruses they've encountered, so they can rapidly respond to new infections from those viruses," says the study's author, Gordon Freeman, PhD, of Dana-Farber. In the case of chronic infection, however, senior author Rafi Ahmed, PhD, of Emory, has shown that memory cells become exhausted and lose the capacity to respond to the virus. Why this occurs, on a molecular level, has been unclear.

To find the cause, Freeman and his colleagues conducted a "microarray" experiment measuring the activity of thousands of genes in normal memory CD8 T cells in mice and in "exhausted" versions of those cells. They found that a gene known as PD-1 was much more active in the exhausted cells.

From previous research, Freeman's team knew that PD-1 is responsible for a specialized "receptor" in CD8 cells -- a tiny socket for receiving signals from other cells. In 2001, Freeman and his colleagues showed that when the PD-1 receptor latches onto a molecule called PD-L1, the immune system's response to infection is weakened. Freeman's team made antibodies to block this interaction.

"When [co-author] John Wherry of the Wistar Institute found a high level of the PD-1 gene in microarray experiments, we wanted to test whether thi
'"/>

Contact: Bill Schaller
william_schaller@dfci.harvard.edu
617-632-5357
Dana-Farber Cancer Institute
28-Dec-2005


Page: 1 2 3

Related biology news :

1. Study begins to reveal clues to the cause and progression of sepsis
2. Study finds gender differences in renal and other genes contributing to blood pressure
3. Study suggests estrogen deficiency can lead to obesity-induced high blood pressure after menopause
4. Study: Sticking to the sand might not be such good, clean fun for beachgoers
5. Study points to new way to predict death risk from torn aorta
6. Study identifies new gene therapy tools for inherited blindness
7. Study finds contaminated water reaching Floridas offshore keys
8. Study sheds light on why humans walk on two legs
9. Study explains how pathogens evolve to escape detection
10. Study finds hereditary link to premenstrual depression
11. Study identifies energy efficiency as reason for evolution of upright walking

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/9/2019)... ... March 08, 2019 , ... Ace Laboratories, Inc. ... resveratrol + ribose hard candy lozenges ( http://www.well-mints.com ). , Well-Mints™ each contain ... hard candy base dusted with powdered sugar. , Well-Mints'™ patented technology delivers resveratrol ...
(Date:3/1/2019)... , ... February 28, 2019 , ... Teresa Krabbe, Ph.D., ... Isar of the Technical University Munich, has been awarded an xCELLigence Research Grant for ... improved oncolytic virus platform. , Oncolytic viruses represent an exciting new aspect ...
(Date:2/22/2019)... ... February 20, 2019 , ... RoosterBio, Inc, a privately held ... footprint in Frederick, MD after a year of rapid growth. , “Hundreds of ... cell (hMSCs) products to streamline their product development efforts in the regenerative medicine ...
Breaking Biology News(10 mins):
(Date:3/19/2019)... Calif. (PRWEB) , ... March 19, 2019 , ... Bogey was nine years old when ... arthritis in his left hip. These ailments caused Bogey to experience problems with his ... vehicles, up stairs, and onto his special spot on the couch. , His owners, devastated ...
(Date:3/19/2019)... ... March 19, 2019 , ... ... hospital in Israel and the Middle East region, and Swiss-based CDMO Lonza ... manufacturing platform. The partnership will enable Sheba to vastly streamline its in-house ...
(Date:3/15/2019)... ... March 15, 2019 , ... ... Inc. and affiliate companies including AVAPCO LLC and API Intellectual Properties Holdings. ... Biorefinery and R&D center in Thomaston, Georgia, operations, research, and business development ...
(Date:3/14/2019)... , ... March 14, 2019 , ... ... Conference & Expo, themed “Navigating the Full Spectrum of Case Management,” continues as ... 10-14, 2019. This conference is the only case management industry conference serving the ...
Breaking Biology Technology:
Cached News: