HOME >> BIOLOGY >> NEWS
Subtle changes in normal genes implicated in breast cancer

BOSTON--Using a super-efficient method they invented to search for a type of cancer-related change in all genes of a cell, Dana-Farber Cancer Institute researchers have discovered new evidence about how the "microenvironment" of breast cancers helps drive the cancers' growth and migration.

The scientists found that non-cancerous cells surrounding young breast cancers -- the microenvironment -- undergo epigenetic modifications. (Epigenetic modifications affect genetic function and are passed along to the cell's offspring, but they don't alter a gene's actual structure or DNA.) The subtly altered gene function causes the microenvironment cells to send signals to the breast tumor cells to grow fast and become more aggressive.

"This is the first demonstration that epigenetic occur in the supportive cells of a tumor, and this further emphasizes that surrounding cells play an active role in cancer formation and growth," says Kornelia Polyak, MD, PhD. "These changes in the microenvironment may occur before breast duct cells undergo genetic changes that cause cancer, thus detecting the epigenetic alterations may be a means of early cancer diagnosis or even predicting cancer risk."

Polyak is senior author of the paper, which was posted this week as an advance online publication on the Nature Genetics web site, http://www.nature.com/ng. The first author of the paper is Min Hu, PhD, of Dana-Farber.

Polyak and her colleagues had previously shown that the genes in the microenvironment surrounding the breast's milk ducts were overactive, and that they continued to be overactive when their cells reproduced, even though their DNA had not been altered. She suspected that the methylation state of the cells' DNA was being inherited. A gene's activity can be regulated by a kind of chemical switch process, methylation, when units called methyl groups are added or removed from the gene's DNA. The on-off
'"/>

Contact: Bill Schaller
william_schaller@dfci.harvard.edu
617-632-5357
Dana-Farber Cancer Institute
13-Jul-2005


Page: 1 2 3

Related biology news :

1. Subtle signs can help predict Huntingtons disease early
2. Acute sleep deprivation leads to changes in nighttime urine production for men and women
3. Marine phytoplankton changes form to protect itself from different predators
4. ENCODE map changes view of the human genome landscape
5. Small-scale agricultural changes may help eradicate widespread disease
6. Nanotechnology requires immediate changes in EPA
7. K-State to collaborate on research to forecast ecological consequences of environmental changes
8. Scientists: As rainfall changes, tropical plants may acclimate
9. Fish growth changes enhanced by climate change
10. Common fungicide causes long-term changes in mating behavior
11. New report: Explosive growth changes salmon industry

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/28/2020)... ... June 25, 2020 , ... Genedata, ... that it has entered into a multi-year contract with Merus N.V., a ... translational and clinical research strategy to discover and develop ground-breaking drugs. The ...
(Date:6/23/2020)... ... June 23, 2020 , ... ... monoclonal antibody development services, today announced that the company has received ISO9001:2015 ... the pharmaceutical, diagnostics, and research industries. The decision to pursue ISO9001 accreditation ...
(Date:6/23/2020)... WOODLNDS, Texas (PRWEB) , ... June 23, 2020 ... ... X-ray analytical instrumentation, is pleased to announce the next event in a series ... X-ray scattering. , The TOPIQ series of webinars was developed in response to ...
Breaking Biology News(10 mins):
(Date:7/18/2020)... ... 2020 , ... Medial EarlySign , a leader in ... high-burden diseases, and Centric Consulting, a business and technology consulting firm, today announced ... in order to identify and prioritize patients for care. , Combining Centric’s management ...
(Date:7/10/2020)... ... July 09, 2020 , ... ... that Massachusetts Institute of Technology (MIT) has expanded the company’s exclusive license ... to move into the point-of-care diagnostic market, focusing initially on the SARS-CoV-2 ...
(Date:7/7/2020)... ... July 06, 2020 , ... R3 International is now offering stem cell ... million stem cells. Depending on the patient's condition, treatment may be offered IV, intrathecal ... having some form of Alzheimers dementia, and the incidence continues to increase as individuals ...
(Date:7/1/2020)... ... June 29, 2020 , ... The ... purchasing contracts to its membership, recently named BioFit Engineered Products an ... opportunity to purchase ergonomic seating, cafeteria tables, book trucks and carts at discounted ...
Breaking Biology Technology:
Cached News: