HOME >> BIOLOGY >> NEWS
Success or failure of antidepressant citalopram predicted by gene variation

A variation in a gene called GRIK4 appears to make people with depression more likely to respond to the medication citalopram (Celexa) than are people without the variation, a study by the National Institute of Mental Health (NIMH), part of the National Institutes of Health, has found. The increased likelihood was small, but when people had both this variation and one in a different gene shown to have a similarly small effect in an earlier study, they were 23 percent more likely to respond to citalopram than were people with neither variation.

The finding addresses a key issue in mental health research: the differences in peoples responses to antidepressant medications, thought to be based partly on differences in their genes. Some patients respond to the first antidepressant they attempt, but many dont. Each medication takes weeks to exert its full effects, and patients depression may worsen while they search for a medication that helps. Genetic studies, such as the one described here, may lead to a better understanding of which treatments are likely to work for each patient.

Results of the study are in the August issue of the American Journal of Psychiatry, reported by lead researcher Francis J. McMahon, MD, Silvia Paddock, PhD, of NIMH, and colleagues. Scientists from the National Human Genome Research Institute, the National Institute on Alcohol Abuse and Alcoholism, Mount Sinai School of Medicine, and University of Texas Southwestern Medical Center also contributed to the research.

Were moving steadily closer to being able to personalize treatments based on patients genetic variations. This is a crucial need for the millions of Americans who suffer from depression, said NIMH Director Thomas R. Insel, MD. New techniques have led to advances that would have been inconceivable a few years ago and are making individualized treatment an achievable goal.

The researchers studied DNA provided earlier by patients participating in a recently comp
'"/>

Contact: Susan Cahill
scahill@mail.nih.gov
301-443-4536
NIH/National Institute of Mental Health
1-Aug-2007


Page: 1 2 3

Related biology news :

1. Success rates for prostate cancer depend on experience of surgeon
2. Successful development of prototype assays
3. Successful lung cancer surgery not enough to break nicotine dependence in many smokers
4. Successful one year gene therapy trial for Parkinsons disease announced by Neurologix
5. Successful transplantation from pig embryos to mice
6. Success comes at a cost, even for phages
7. Successful cell engineering may lead to mad cow prevention, say researchers
8. Success tastes sweet for scientists
9. Successful test of single molecule switch opens the door to biomolecular electronics
10. High blood pressure, low energy -- a recipe for heart failure
11. Specific type of cell death may accelerate decompensated heart failure

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/16/2017)... 16, 2017   Bridge Patient Portal , ... MD EMR Systems , an electronic medical ... GE, have established a partnership to build an ... the GE Centricity™ products, including Centricity Practice Solution ... These new integrations will allow healthcare delivery ...
(Date:4/17/2017)... NXT-ID, Inc. (NASDAQ: NXTD ) ("NXT-ID" or the "Company"), ... Report on Form 10-K on Thursday April 13, 2017 with the ... The ... section of the Company,s website at http://www.nxt-id.com  under "SEC Filings," ... 2016 Year Highlights: Acquisition of ...
(Date:4/11/2017)... N.Y. , April 11, 2017 ... fingerprints, but researchers at the New York University ... College of Engineering have found that partial similarities ... security systems used in mobile phones and other ... thought. The vulnerability lies in the ...
Breaking Biology News(10 mins):
(Date:10/12/2017)... ... October 12, 2017 , ... ... Rosalind™, the first-ever genomics analysis platform specifically designed for life science researchers ... honor of pioneering researcher Rosalind Franklin, who made a major contribution to ...
(Date:10/11/2017)... ... October 11, 2017 , ... Proscia ... be hosting a Webinar titled, “Pathology is going digital. Is your lab ready?” ... pathology adoption best practices and how Proscia improves lab economics and realizes an ...
(Date:10/11/2017)... ... October 11, 2017 , ... Singh Biotechnology ... drug designation to SBT-100, its novel anti-STAT3 (Signal Transducer and Activator of Transcription ... is able to cross the cell membrane and bind intracellular STAT3 and inhibit ...
(Date:10/10/2017)... 2017 International research firm Parks Associates announced today ... the TMA 2017 Annual Meeting , October 11 in ... home security market and how smart safety and security products impact the ... Parks Associates: Smart Home Devices: ... "The residential security market has experienced ...
Breaking Biology Technology:
Cached News: