HOME >> BIOLOGY >> NEWS
Super fruit fly may lead to healthier humans

In a triumph for pests, scientists have figured out how to make the fruit fly live longer.

But humans still may get something out of the deal. As reported online in Nature Chemical Biology, the discovery that a single protein can inhibit aging holds implications for human longevity and for treatment of some of the worlds most feared diseases.

This work is important for two reasons, said study author Richard Roberts, associate professor of chemistry, chemical engineering and biology at the University of Southern California.

First, it demonstrates that a single inhibitor can dramatically alter lifespan, a very complex trait. It is remarkable that you can alter it with a single genetic change.

We dont really need to make fruit flies live longer, but if we understand how to do this, our approach may have direct application to higher organisms, such as ourselves.

Secondly, Roberts said, the method used by his research group to make the inhibiting proteins opens the possibility of developing a lot of new therapeutics.

The study describes a new method for blocking receptors involved in aging and disease across many species, including humans.

Receptors are proteins that transmit signals across a cell membrane. In the fruit fly, Roberts and his team manufactured short proteins that blocked a receptor involved in fruit fly aging, as previously demonstrated by co-author Seymour Benzer of Caltech.

Flies with a blocked receptor saw their lives extended by a third, with no apparent side effects.

The same blocking strategy should work in all such receptors, known as class B GPCRs (for G protein-coupled receptors). Many GPCRs figure prominently in disease as well as in normal development, Roberts said.

It is the most targeted family of receptors by drug manufacturers, Roberts said, estimating that a quarter of all pharmaceuticals focus on GPCR
'"/>

Contact: Carl Marziali
marziali@usc.edu
213-740-4751
University of Southern California
7-Jun-2007


Page: 1 2

Related biology news :

1. Nitrate in Lake Superior: On the rise
2. Supermap of avian flu yields new info on source/spread
3. Super small nanoelectrodes can probe microscale environments
4. Super-fermenting fungus genome sequenced
5. Super-thin membrane, 50 atoms thick, sorts individual molecules
6. Microsurgery and Super Glue show how antennae aid moth navigation
7. Supercomputing equipment to advance the frontiers of computational biology
8. Super chow, laced with semi-synthetic vitamin E derivative, inhibited spread of cancer in mice
9. Super blackcurrants with boosted vitamin C
10. Supercomputers to transform science
11. Super-sized cassava plants may help fight hunger in Africa

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/13/2020)... ... 13, 2020 , ... Murrieta Genomics , the provider of genomics services ... learn event on February 25th from 11:30 am to 1 pm at the University ... public are invited to attend this free event, but must register in advance ...
(Date:2/11/2020)... ... February 11, 2020 , ... ... sciences companies and government agencies, announced the recent appointment of Jonathan Horn ... Tunnell, with significant experience assessing, designing, and managing enterprise transformation initiatives, especially ...
(Date:2/6/2020)... (PRWEB) , ... February 06, 2020 , ... ... to facilitate access to unique lab-made bioresearch materials, today announced an agreement with ... and plant-based meat and seafood a reality. Under the partnership, terrestrial meat and ...
Breaking Biology News(10 mins):
(Date:2/11/2020)... ... February 11, 2020 , ... ... pleased to announce the successful results from a long-term follow-up clinical study ... Inspan interspinous fixation device (INSPAN LLC). Unlike extension block design, the Inspan ...
(Date:2/10/2020)... ... February 10, 2020 , ... R3 Medical Training announced ... March 13-14th, 2020 in Las Vegas. The course is hands on involving real patients ... the past few years, the Comprehensive Stem Cell Training Course has received rave reviews ...
(Date:2/5/2020)... Fla. (PRWEB) , ... February 05, 2020 , ... ... annual observance, sponsored by The National Organization for Rare Disorders (NORD), to raise awareness ... lives ( rarediseaseday.org ). The Balancing Act’s “Behind The Mystery” rare disease ...
(Date:2/3/2020)... ... February 03, 2020 , ... ... Cambridge, MA, announce that OmniType, the 11-locus, single tube multiplex successor to Holotype ... a best-in-class product featuring locus-multiplexing and short library preparation, for HLA genotyping from ...
Breaking Biology Technology:
Cached News: