HOME >> BIOLOGY >> NEWS
Surprising origin of cell's internal highways

Scientists have long thought that microtubules, part of the microscopic scaffolding that the cell uses to move things around in order to hold its shape and divide, originated from a tiny structure near the nucleus, called the centrosome.

Now, researchers at Vanderbilt University Medical Center reveal a surprising new origin for these cellular "highways." In the June issue of Developmental Cell, Irina Kaverina, Ph.D., and colleagues report that the Golgi apparatus -- a stack of pancake-shaped compartments that sorts and ships proteins out to their cellular destinations -- is the source of a particular subset of these microscopic fibers. The findings point to a novel cellular mechanism that may guide cell movement and possibly cancer cell invasion.

Microtubules are the largest of the three main types of filaments that make up the cytoskeleton -- a web of microscopic fibers inside the cell.

They form when two globular proteins, alpha- and beta-tubulin, polymerize into long chains, which then assemble into long, hollow tubes. In order to gain a foothold, nascent microtubule "seeds" must be anchored at a structure near the cell's nucleus called the centrosome or microtubule-organizing center (MTOC).

From the MTOC, the growing microtubules launch out in all directions to the cell's periphery. Their rapid assembly and disassembly helps transport proteins throughout the cell and generate polarized (directional) signal distribution that causes cells to move.

While microtubules in some specialized cells can originate from non-centrosomal structures, the centrosome has been considered the main origination point for microtubule "nucleation" in most cells. Until now.

"I've seen that there are lots of microtubules not attached to the centrosome," said Kaverina, assistant professor of Cell and Developmental Biology and senior author on the paper. "So I am trying to look at their origins."

The Golgi has
'"/>

Contact: Melissa Marino
melissa.marino@vanderbilt.edu
615-322-4747
Vanderbilt University Medical Center
20-Jun-2007


Page: 1 2 3

Related biology news :

1. Surprising new species of light-harvesting bacterium discovered in Yellowstone
2. Surprising airbag hazards among research findings at hearing safety conference
3. Surprising symbiosis: Glassy-winged sharpshooter eats with friends
4. Surprising genetic differences id-ed in southern house mosquito
5. Surprising killer of southeastern salt marshes: Common sea snails
6. Growing lymph vessels with macrophages? Surprisingly, yes!
7. Surprisingly complex behaviors appear to be hard-wired in the primate brain
8. Surprising study reveals how cancer-causing protein activates
9. Discredited Korean embryonic stem cells true origins revealed
10. New research proves single origin of humans in Africa
11. The origin of perennial water-ice at the South Pole of Mars

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:7/24/2019)... ... 24, 2019 , ... NDA Partners Chairman Carl Peck, ... more than 20 years of experience working in scientific research and FDA-regulated environments ... an Expert Consultant. , Dr. Hartzfeld has experience in all aspects of quality, ...
(Date:7/23/2019)... ... , ... NanoFUSE is pleased to announce the ... spine and orthopedic use. Bioactive glass is a calcium phosphate coated silica that ... orthopedics for over 30 years and now NanoFUSE Biologics has used advanced research ...
(Date:7/19/2019)... ... July 19, 2019 , ... ... and Crystalline States – Insights from Synchrotron X-ray Pair Distribution (SXPDF) Studies”. The ... with Chris Benmore of Argonne National Laboratory and Gabriel de Araujo of the ...
Breaking Biology News(10 mins):
(Date:8/6/2019)... , ... August 06, 2019 , ... ... University Edwardsville for the launch of a community project that will engage middle ... grant supports the project, entitled “A Youth-Led Citizen Science Network for Community Environmental ...
(Date:7/30/2019)... ... July 30, 2019 , ... The summer ... cooking events company. Not only has the company already hosted many of its ... Cooking Parties to its guests. , With Lajollacooks4u’s Private Cooking Parties, guests prepare ...
(Date:7/23/2019)... ... July 22, 2019 , ... While today Visikol is ... fields of 3D tissue imaging , digital pathology , 3D ... in 2013 as a products company. These products are focused on addressing the ...
(Date:7/19/2019)... ... July 18, 2019 , ... ... Everest,” will be joining forces with California-based charity Coalition Duchenne for its 9th ... Coalition Duchenne raises awareness and funding for Duchenne muscular dystrophy and was founded ...
Breaking Biology Technology:
Cached News: