Their findings could lead to the development of smarter drugs or gene therapies to halt the progress of neurological diseases like Alzheimer's and Parkinson's disease and may also explain, scientifically, the benefits to the brain of maintaining an intellectually and physically stimulating lifestyle in later years.
Dr Giles Hardingham of the Centre for Neuroscience Research at the University of Edinburgh said: "When brain cells are highly stimulated, many unused genes are suddenly reactivated. We have found that a group of these genes can make the active brain cells far healthier than lazy, inactive cells, and more likely to live a long life. These findings also have implications at the other end of life, where maternal drug taking and drinking can cause these survival genes to be turned off in the brain of unborn babies."
Dr Hardingham, who presented this work recently at the prestigious annual meeting for the Society for Neuroscience in Washington DC, explained: "We recently discovered that a critical step in turning on these survival genes involves activating a master genetic controller called CREB. We aim to home in on which of these CREB-controlled genes are crucial in helping the brain cells live longer and become resistant to trauma. By being able to explain at molecular level the basis of brain activity-dependent survival, it will open the way to developing better ther
Contact: Linda Menzies
University of Edinburgh