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Susceptibility to Crohn's disease -- an important new clue

Crohns disease is a chronic relapsing inflammatory disorder of the intestinal tract that affects an estimated 0.15% of people in the developed world. Common symptoms include abdominal pain and diarrhea, but the disorder is often associated with debilitating clinical complications. Researchers from the University of Lige, Belgium, have now uncovered an important clue to the susceptibility of individuals to this disease.

In a genome-wide association study with more than 300,000 single nucleotide polymorphisms (SNPs) DNA sequence variations occurring when a single nucleotide in the genome differs between members of a species Ccile Libioulle et al. identified a new susceptibility locus for Crohns disease. Their results are published online in the open-access journal PLoS Genetics.

Recent advances in SNP genotyping technology have allowed systematic association scanning of the entire genome for the detection of novel susceptibility loci fixed positions on a chromosome, such as the position of a gene. Libioulle and colleagues applied this approach to Crohns disease and identified the key locus on chromosome 5.

Individual susceptibility to many common diseases, including Crohns disease, is determined by a combination of environmental and genetic factors and identifying these genetic risk factors is one of the most important objectives of modern medical genetics, potentially paving the way towards personalized medicine and drug target identification.


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Contact: Michel Georges
michel.georges@ulg.ac.be
324-366-4151
Public Library of Science
20-Apr-2007


Page: 1

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