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Symptoms of depression may worsen heart failure

COLUMBUS , Ohio New research suggests that depression may hasten the progression of heart disease by increasing the levels of a key protein that causes inflammation.

In a study of 32 people with heart failure, the 14 patients who felt the most depressed had nearly twice the levels of this protein in their blood.

The protein, tumor necrosis factor alpha (TNF-alpha), is one member of a large family of proteins called cytokines, chemical messengers that are mobilized when the body is injured or has an infection. These cytokines often cause inflammation in their effort to repair an injured or infected area of the body. In the case of heart failure, this inflammation makes it even more difficult for the heart to pump blood. (Heart failure is a disease in which the heart loses the ability to pump blood with normal efficiency.)

"People with heart failure typically have much higher TNF-alpha levels than people without the disease," said Amy Ferketich, the study's lead author and an assistant professor of public health at Ohio State.

"But depression seems to make levels of this cytokine even higher, which is bad for patients."

The study's results appear in a recent issue of the American Heart Journal. Ferketich worked with Ohio State colleagues Jeanette Pohorence Ferguson, a graduate student in pathology, and Philip Binkley, a professor of internal medicine.

They recruited 32 patients from the heart failure clinic at Ohio State . The participants answered the 21-question Beck Depression Inventory, a tool that physicians and scientists use to measure symptoms of depression. Answers to each question are given a value of zero (no symptoms at all) to 3 (severe symptoms). A score of 10 or more suggests that a patient has at least mild symptoms of depression.

The researchers drew blood samples from each patient. From these samples they evaluated levels of three cytokines: TNF-alpha, interleukin-6 (IL-6) and interleuki
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Contact: Amy Ferketich
Aferketich@sph.osu.edu
614-293-4387
Ohio State University
7-Sep-2005


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