HOME >> BIOLOGY >> NEWS
Tagging pathogens with synthetic DNA 'barcodes'

ITHACA, N.Y. -- A supermarket checkout computer can identify thousands of different items by scanning the tiny barcode printed on the package. New technology developed at Cornell University could make it just as easy to identify genes, pathogens, illegal drugs and other chemicals of interest by tagging them with color-coded probes made out of synthetic tree-shaped DNA.

A research group headed by Dan Luo, Cornell assistant professor of biological engineering, has created "nanobarcodes" that fluoresce under ultraviolet light in a combination of colors that can be read by a computer scanner or observed with a fluorescent light microscope.

Other methods of identifying biological molecules that are available or being developed mostly involve expensive equipment, Luo said. "We wanted something that could be done with inexpensive, readily available equipment," he said. Several years ago researchers created probes consisting of nanoscale bars of metal actually etched with conventional bar codes. Since then, most molecular tagging devices have been referred to as "barcodes," even though there are no bars involved.

The researchers have tested their system using samples containing various combinations of E. coli, anthrax and tularemia bacteria and ebola and SARS viruses, and have found the color codes could clearly distinguish several different pathogens simultaneously.

The research is described in a paper, "DNA fluorescence nanobarcodes for multiplexed pathogen detections," by Luo, Yougen Li, a former Cornell graduate student now at California Institute of Technology, and Yen Thi Hong Cu, a current graduate student, to be published in the July 2005 issue of the journal Nature Biotechnology and available after June 12 in the online version of the journal.

The idea is one of several applications the researchers have found for what they call "dendimer-like DNA," consisting of many short Y-shaped strands of DNA linked together in a treelike structure. The
'"/>

Contact: Blaine P. Friedlander Jr.
bpf2@cornell.edu
607-254-8093
Cornell University News Service
13-Jun-2005


Page: 1 2 3

Related biology news :

1. Study explains how pathogens evolve to escape detection
2. A stepwise retreat: How immune cells catch pathogens
3. More swimmers means more pathogens in the water
4. Sandia researchers take new approach to studying how cells respond to pathogens
5. Researchers find best way to detect airborne pathogens
6. The price of vanity: Mating with showy males may reduce offsprings ability to fight off pathogens
7. New highways carry pathogens and social change in Ecuador
8. Researchers map spread of pathogens in the human body
9. Researchers develop technologies to devour food pathogens
10. Fight weeds with plant pathogens
11. Sequences reveal benign origin of deadly plant pathogens

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:7/23/2019)... ... , ... NanoFUSE is pleased to announce the ... spine and orthopedic use. Bioactive glass is a calcium phosphate coated silica that ... orthopedics for over 30 years and now NanoFUSE Biologics has used advanced research ...
(Date:7/19/2019)... ... July 19, 2019 , ... ... and Crystalline States – Insights from Synchrotron X-ray Pair Distribution (SXPDF) Studies”. The ... with Chris Benmore of Argonne National Laboratory and Gabriel de Araujo of the ...
(Date:7/17/2019)... Pa. (PRWEB) , ... July 15, 2019 , ... ... of computational science expertise exclusively for Life Sciences and Healthcare companies, announces the ... provide critical advisory services and strategic direction to start-up and emerging bio-pharma companies ...
Breaking Biology News(10 mins):
(Date:6/11/2019)... Fla. (PRWEB) , ... June 10, 2019 , ... ... in science and technology in an upcoming episode, scheduled to broadcast 4Q/2019. Check ... the Eppendorf Group) and will educate viewers about how its technology facilitates laboratories ...
(Date:6/11/2019)... POWAY, Calif. (PRWEB) , ... June 11, 2019 ... ... parent company of Personalized Stem Cells Inc. (PSC) , has announced that ... of Public Health, Food and Drug Branch for manufacturing. This is an ...
(Date:5/31/2019)... ... May 29, 2019 , ... For many years, the primary forms of cancer ... breakthrough therapies. Advances in immuno-oncology have led to the advent of Chimeric Antigen Receptor ... T cell receptors known as “CARs”. The CAR enables the final product to produce ...
(Date:5/31/2019)... ... May 30, 2019 , ... Object ... announce the strategic acquisition of Metabiologics, Inc., a globally recognized leader in the ... ownership and commercialization rights to a full spectrum of botulinum neurotoxins, as well ...
Breaking Biology Technology:
Cached News: