HOME >> BIOLOGY >> NEWS
Taking 'chips' to the next level of gene hunting

Researchers at the Johns Hopkins' High Throughput Biology Center have invented two new gene "chip" technologies that can be used to help identify otherwise elusive disease-causing mutations in the 97 percent of the genome long believed to be "junk."

A variety of DNA microarray technology, one of the two new chips, called the TIP-chip (transposable element insertion point) can locate in the genome where so-called jumping genes have landed and disrupted normal gene function. This chip is described online this week in the Proceedings of the National Academy of Sciences.

The most commonly used gene chips are glass slides that have arrayed on them neat grids of tiny dots containing small sequences of only hand-selected non-junk DNA. TIP-chips contain on them all DNA sequences. Because each chip can hold thousands of these dots - even a whole genome's worth of information - scientists in the future may be able to rapidly and efficiently identify, by comparing a DNA sample from a patient with the DNA on the chip, exactly where mutations lie.

"With standard chips, we're missing a big piece of the picture of mutations in humans because they look only at the meaty parts of genes, but the human genome is only 3 percent meaty parts," says Jef Boeke, Ph.D., Sc.D, professor of molecular biology and genetics and director of the HiT (High Throughput Biology Center), who spearheaded both studies at the Institute of Basic Biomedical Sciences at Hopkins. "The other 97 percent also can contain disease-causing mutations and is often systematically ignored," he says.

Boeke and his team have focused particularly on transposable elements, segments of DNA that hop around from chromosome to chromosome. These elements can, depending on where they land, wrongly turn on or off nearby genes, interrupt a gene by lodging in the middle of it, or cause chromosomes to break. Transposable elements long have been suspected of playing a role vital to disease-c
'"/>

Contact: Audrey Huang
audrey@jhmi.edu
410-614-5105
Johns Hopkins Medical Institutions
14-Nov-2006


Page: 1 2 3

Related biology news :

1. Taking a supplement of glycine helps prevent degenerative diseases such as arthrosis or osteoporosis
2. Taking heart failure to the MAT1
3. Vax and Pax: Taking turns to build an eye
4. Taking evolutions temperature: Researchers pinpoint the energy it takes to make a species
5. Taking a bite out of a fellow worker helps wasps recruit new foragers
6. Taking a break from fractures: A closer look at vitamin D
7. Taking a flying jump
8. Taking the piste out of Alpine vegetation
9. Taking the next step toward growing our own fuel
10. Researchers watch antibiotics, bacteria meet at atomic level
11. Eat fish -- especially if you drink high levels of alcohol

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/3/2020)... ... March 03, 2020 , ... Amplify Surgical, Inc., today announces that the company ... System. , The landmark case was performed by Dr. Ali Najafi at ... noted, “dualX has completely changed the game for expandable interbodies. The ability to ...
(Date:3/2/2020)... , ... March 02, 2020 , ... Nominations are now ... co-founded by the Security Industry Association (SIA) and SecureIDNews and ... Women in Security Forum . The recipients of this year’s Women in Biometrics Awards ...
(Date:2/28/2020)... ... February 27, 2020 , ... ... explore innovative treatment solutions for maladies, such as Inflammatory Bowel Disease (IBD), specifically ... This segment will focus on a novel platform developed by Deka Biosciences, Inc. ...
Breaking Biology News(10 mins):
(Date:3/27/2020)... ... March 25, 2020 , ... Enso ... centrally in the midwest for high-quality, quick-turn, board-certified reporting. In an effort ... independent, professional team that is focused on incredible quality, turnaround time and ...
(Date:3/19/2020)... FREDERICK, Md. (PRWEB) , ... ... ... announces a clinical supply and manufacturing collaboration agreement with pioneering gene circuit ... gene-modified cell therapies for ovarian cancer and other solid tumor indications. The ...
(Date:3/13/2020)... ... March 12, 2020 , ... ... APC Microbiome Ireland SFI Research Center (APC), a pioneer in the field of ... and play a significant role in human health, based at University College Cork ...
(Date:3/10/2020)... ... 10, 2020 , ... Ortho Clinical Diagnostics, a global leader of in vitro ... Sera, ID-MTS, a suite of extended antigen in a gel testing format used for ... VISION® and ORTHO VISION® Max in the United States and Canada. The clearances allow ...
Breaking Biology Technology:
Cached News: