Targeting key proteins of carcinogenesis

among experts.

A prerequisite for the E3-independent reaction is the presence of a Ub-binding domain (UBD) in the protein that is able to recognize Ub. This type of protein is of utmost importance for the cell because it can distinguish between ubiquitinated and non-ubiquitinated proteins, explains Dr. Daniela Hoeller, the responsible scientist. UBD-proteins are the key to the effects of Ub both in normal and malignant cells.

Dikic and his coworkers demonstrated that proteins equipped with an UBD can ubiquitinate themselves by directly recruiting Ub-loaded E2 enzymes thus making E3 ligases dispensible. In their previous work Hoeller and Dikic showed that the ubiquitination of UBD proteins does not lead to their degradation but rather causes their functional inactivation. In other words they become unable to recognize and control ubiquitinated proteins. If needed the cell can re-activated them by cleaving the attached Ub. In this way the cell can quickly and dynamically react on external signals.

The discovery provides the basis for novel therapeutic approaches that are more specific than drugs like Bortezomib. For an effective therapeutic use there is still a long way to go, explains Mller-Esterl, who needs to update his biochemistry textbook now.


Contact: Ivan Dikic
Johann Wolfgang Goethe-Universitt Frankfurt

Page: 1 2

Related biology news :

1. Targeting tumors the natural way
2. Targeting the adrenal gland could be key strategy against heart failure, Jefferson scientists show
3. Targeting tau: Inflammation study suggests new approach for fighting Alzheimers
4. Best of both worlds -- Targeting a single gene could inhibit bone decay and stimulate bone growth
5. Targeting wolbachia, doxycycline reduces pathology of lymphatic filariasis
6. Targeting lung cancer
7. Targeting the dosage compensation complex
8. Targeting pancreatic cancer
9. Targeting a key enzyme with gene therapy reversed course of Alzheimers disease in mouse models
10. Targeting tumor growth
11. UCF research links proteins, stem cells and potential Alzheimers treatment

Post Your Comments:

(Date:9/26/2015)... 26th, 2015  Results of a TactioRPM pilot ... today at the Stanford Medicine X Conference. In ... Dashboards, Connected Health Devices and Pharmacogenomics", Roger ... will explain how senior patients equipped with connected ... pharmacist via the TactioRPM remote patient monitoring platform ...
(Date:9/24/2015)... September 24, 2015 ... 2015 Kerv ( http://kerv.com ... lanserar idag världens första kontaktlösa betalningsring på ... 77 000 GBP för massproduktion via crowdfunding.  ... ) , Kerv-bärare kan göra ...
(Date:9/10/2015)... -- Report Details Emerging Biological Drugs ... Revenue Prospects to Help You Stay Ahead ... drug classes? Get the latest technological and commercial ... data and industry knowledge, benefitting your influence. And ... sales predictions. Visiongain,s new study reveals what,s ...
Breaking Biology News(10 mins):
(Date:10/12/2015)... , Oct. 12, 2015 /PRNewswire/ - Aeterna Zentaris ... biopharmaceutical company engaged in developing and commercializing novel treatments ... departure of Dennis Turpin , the Company,s former ... to close its Quebec City ... President and Chief Executive Officer of the Company commented, ...
(Date:10/12/2015)... LabStyle Innovations Corp. (OTCQB: ... announced its Medical Director, Dr. Moshe Kamar , ... 5th EAI International Conference on Wireless Mobile Communication and ... mobile and wireless technologies," the conference will take place ... 14 - 16, 2015. The conference is endorsed and ...
(Date:10/12/2015)... , Oct. 12, 2015 VolitionRx Limited ... completed clinical study of its NuQ ® blood-based test ... online issue of Clinical Epigenetics , the official journal ... in collaboration with Lund University, ... , MD, PhD, Professor of Surgery and Vice-Dean, Faculty of ...
(Date:10/12/2015)... ... October 12, 2015 , ... NeuMedics Inc., is a specialty biopharmaceutical ... that can safely and chronically be administered as an eye drop, announced today it ... The Cleveland Clinic and taking place October 25th to October 28th at The Cleveland ...
Breaking Biology Technology:
Cached News: