HOME >> BIOLOGY >> NEWS
Teamwork between 2 key proteins necessary for normal development and regulation of red blood cells

RICHMOND, Va. (Aug. 6, 2007) Virginia Commonwealth University researchers studying hemoglobin genes, mutations of which play a role in genetic blood disorders like sickle cell anemia and beta-thalassemia, have identified two proteins that are responsible for regulating overlapping groups of genes during the development of red blood cells.

The findings may point researchers to future gene therapies for patients with sickle cell anemia and beta-thalassemia.

In an article pre-published online Aug. 3 as a First Edition Paper in the journal Blood, the journal of the American Association for Hematology, researchers reported that a protein called KLF2 coordinates with a related and well-studied transcription factor, EKLF, in the regulation of embryonic globin genes responsible for the development of mouse embryonic red blood cells.

EKLF plays a central role in the developmental regulation of the adult beta-globin gene, and is essential for the maturation and stability of adult red blood cells. KLF2 is a protein crucial for making embryonic red blood cells.

If EKLF and KLF2 can turn on the embryonic globin genes in adult cells we don't know if this is true yet - then these findings may provide a gene therapy approach for treating sickle cell anemia and beta-thalassemia. It is well-established that the expression of embryonic globin genes can help ameliorate these diseases, said Joyce A. Lloyd, Ph.D., associate professor of human genetics at the VCU Massey Cancer Center, and corresponding author for this study.

Lloyds team studied gene expression and red blood cell development in the mouse embryo. They used mouse embryos missing both the KLF2 and EKLF genes to show that embryonic globin expression is severely reduced, and that the embryos therefore are anemic, compared to mice missing KLF2 or EKLF alone.

This likely means that EKLF and KLF2, which are related transcription factors, regulate overlapping grou
'"/>

Contact: Sathya Achia-Abraham
sbachia@vcu.edu
804-827-0890
Virginia Commonwealth University
6-Aug-2007


Page: 1 2

Related biology news :

1. New textbook illuminates the close links between evolutionary and molecular biology
2. Link between sunspots, rain helps predict disease in east Africa
3. Link identified between Alzheimers disease and glaucoma
4. Human knowledge is based upon directed connectivity between brain areas
5. First case of successful ovarian tissue transplantation between two, nonidentical sisters
6. Strength of connections between brain regions may affect an adolescents response to peer influence
7. MIT IDs link between brain tumor proteins
8. Co-operation between GSF and clinic improves outlook for sarcoma patients
9. FDA finds no strong link between tomatoes and reduced cancer risk
10. Link between immune system and mammary gland could shed new light on breast cancer
11. Satellite images reveal link between urban growth and changing rainfall patterns

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/23/2020)... (PRWEB) , ... June 22, 2020 , ... The field ... Typically, ligand binding assays (LBA) have dominated this area. However, the use of mass ... years. , This now necessitates the question “How do you choose which approach to ...
(Date:6/19/2020)... ... ... Join experts from Envigo Lauren Klaskala, Project Manager – Custom Transgenic Models ... July 8, 2020 at 11am EDT (4pm BST/UK). , Nuclease-based technologies such as CRISPR ... the genome may be more straightforward, the challenge to create an optimal model for ...
(Date:6/5/2020)... ... June 04, 2020 , ... “Although we are disappointed ... well-being of our attendees, staff, and the public. We remain committed to creating ... ways to collaborate virtually,” said Julie Sutcliffe, President of WMIS. , ...
Breaking Biology News(10 mins):
(Date:5/15/2020)... (PRWEB) , ... May 14, 2020 , ... ... to undergo multiple open heart surgeries before becoming adults. The reason: ... , To address this critical unmet need, the Department of Defense has awarded ...
(Date:5/15/2020)... ... , ... Sentien Biotechnologies, Inc., a clinical-stage biotechnology company developing novel approaches to ... Ganz will continue to lead Sentien’s Board of Directors, a role he has filled ... and Sentien’s management team. , Mr. Ganz has more than 30 years ...
(Date:5/14/2020)... ... May 12, 2020 , ... NanoString Technologies ... together thousands of industry leaders, clinicians, research scientists, medical professionals and academics from ... June, MD, Director of the Center for Cellular Immunotherapies at the Perelman School ...
(Date:5/14/2020)... ... May 13, 2020 , ... Early ... readouts, providing little or no information on the drug’s mechanism of action (MOA). ... of compounds by measuring the activity of molecular pathways. This information can complement ...
Breaking Biology Technology:
Cached News: