HOME >> BIOLOGY >> NEWS
Technology captures tumors' genetic profile, guides cancer treatment

BOSTON -- A study led by researchers at Dana-Farber Cancer Institute and Broad Institute of the Massachusetts Institute of Technology and Harvard University provides the first demonstration of a practical method of screening tumors for cancer-related gene abnormalities that might be treated with "targeted" drugs.

The findings, published online today on the Nature Genetics Web site, may help relieve a bottleneck between scientists' expanding knowledge of the genetic mutations associated with cancer and the still nascent ability of doctors to use that knowledge to benefit patients. The results constitute an important step toward the era of "personalized medicine," in which cancer therapy will be guided by the particular set of genetic mutations within each patient's tumor, the authors suggest.

"It's universally recognized that cancer is a disease of the genome, of mutations within genes responsible for cell growth and survival, and a great deal of effort has gone into finding those mutations, to the point where several hundred to a thousand are now known," said the study's senior author, Levi Garraway, MD, PhD, of Dana-Farber and the Broad Institute. "The challenge has been how to determine which of them are involved in each of the hundreds of kinds of cancer that occur in humans -- and to develop accurate, affordable methods of detecting key mutations in tumor samples. This study suggests that such a method is feasible on a large scale."

The authors took advantage of a scientific serendipity to devise a simple test to detect important cancer mutations. Mutations in oncogenes (genes linked to cancer) do not occur randomly; rather, they seem to arise most frequently in certain regions of the oncogenes. As a result, researchers didn't necessarily have to scan the entire length of each gene, but could focus instead on the sections most likely to harbor mutations.

They performed these screenings with a technology known as high-th
'"/>

Contact: Robbin Ray
robbin_ray@dfci.harvard.edu
617-632-4090
Dana-Farber Cancer Institute
11-Feb-2007


Page: 1 2 3

Related biology news :

1. Naval Science and Technology Conference 2007
2. President Bush announces 2005 and 2006 Laureates of National Medals of Science and Technology
3. Technology reveals lock and key proteins behind diseases
4. Delft University of Technology designs language development toy for autistic children
5. Technology exists to keep E. coli out of food
6. Technology helps predict outcome of pediatric heart surgery
7. Ossur recognized with Frost & Sullivan 2006 Innovative Technology Award
8. NRC team uses new Quantum Technology to control molecules
9. Advanced Membrane Technology III: Membrane engineering for process intensification
10. The European Institute of Technology
11. Jane Lubchenco receives the 2005 AAAS Public Understanding of Science and Technology Award

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:7/23/2019)... Calif. (PRWEB) , ... July 22, 2019 , ... Personalized ... for a New Drug (IND) application for use of a person’s own adipose-derived stem ... uses stem cells as a treatment of osteoarthritis in the knee. , ...
(Date:7/19/2019)... ... ... VetStem Biopharma has long been a leader in veterinary stem cell ... two-year research collaboration with Calidi Biotherapeutics, VetStem has signed a worldwide license and development ... be able to fast-track this cancer therapy for use in dogs due to the ...
(Date:7/17/2019)... ... July 17, 2019 , ... ... Southeast, and its acclaimed pediatric urologists are among the professionals honored in ... recognition signifies excellence among the country’s pediatric healthcare landscape. , Georgia Urology’s ...
Breaking Biology News(10 mins):
(Date:7/17/2019)... Md. (PRWEB) , ... July 15, 2019 , ... CRISPR ... so that a certain trait can be removed, replaced, or edited, but Yiping Qi, ... looking far beyond these traditional applications in his latest publication in Nature Plants. In ...
(Date:7/9/2019)... Iowa (PRWEB) , ... July 08, 2019 , ... Today, ... Moines, Iowa, the National Corn Growers Association (NCGA) announced the winners of ... to improve a product or process using field corn to produce biobased materials. , ...
(Date:6/18/2019)... N.J. (PRWEB) , ... June 17, 2019 , ... ... announced that they have entered into an agreement for production and manufacturing of ... for the treatment of rhodopsin-mediated autosomal dominant retinitis pigmentosa (RHO-adRP) and IC-200 for ...
(Date:6/11/2019)... ... 10, 2019 , ... Advancements with Ted Danson will focus ... broadcast 4Q/2019. Check your local listings for more information. , Advancements will explore ... technology facilitates laboratories to improve efficiency and quality of research by providing comprehensive ...
Breaking Biology Technology:
Cached News: