HOME >> BIOLOGY >> NEWS
Telling axons where to go and grow

In a recent study, Dr. Ingolf Bach and colleagues from the University of Massachusetts Medical School, Worcester and the University of Hamburg (Germany) describe a novel role for the ubiquitin/proteosome protein degradation pathway in the regulation of local actin dynamics in neurons.

The authors are able to show that the ubiquitin ligase Rnf6 polyubiquitinates the kinase LIMK1, targeting it for proteosomal degradation in the growth cones of hippocampal neurons. LIMK1 regulates the dynamics of the actin cytoskeleton primarily via phosphorylation of the actin depolymerization factors ADF/cofilin, with important consequences for cell morphology, cell motility, and the development of neuronal projections. Changes in LIMK1 concentration have an impact in neuronal growth cone actin dynamics and axon formation.

The authors focus on the RING finger protein Rnf6 due to its similarity to the previously identified protein RLIM, which has been shown to bind to nuclear LIM domains and critically regulate the biological activity of LIM-HD transcription factors. The authors find high levels of Rnf6 protein in axonal projections of motor neurons and dorsal root ganglia neurons in mouse embryos at a time in which projections are actively developing, suggesting a role of this protein in the development of these neurons. They are able to show that this is indeed the case by RNAi-mediated knock-down of Rnf6 in primary hippocampal neurons, which stimulate axon outgrowth, and by over-expression of Rnf6 that results in a significant decrease in axon length.

Finding that Rnf6 targets LIMK1 for degradation finally closes this circle of regulation, providing the link between actin dynamics, axonal growth and Rnf6. Importantly, the authors are able to show that changes in axon outgrowth induced by changes in levels of Rnf6 can be restored by compensatory changes in LIMK1 expression, thereby giving Rnf6 a central role in controlling actin dynamics in subcellul
'"/>

Contact: Heather Cosel
coselpie@cshl.edu
Cold Spring Harbor Laboratory
30-Sep-2005


Page: 1 2

Related biology news :

1. Telling the likes apart
2. Potent anticancer drug increases function of axons in mouse model of neurodegeneration
3. High-intensity ultrasound may launch attack on cancer, wherever it lurks
4. Waters off Washington state only second place in world where glass sponge reefs found
5. Fruit fly gene from out of nowhere is discovered
6. Where did we come from, and how did we get to where we live today?
7. Why do oysters choose to live where they could be eaten?
8. Unraveling where chimp and human brains diverge
9. Plant studies reveal how, where seeds store iron
10. Unique imaging uncovers the invisible world where surfaces meet
11. Hermaphroditic plants have genetic advantage in areas where extinctions are frequent

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Telling axons where and grow

(Date:8/27/2014)... new skill is easier when it is related to ... pianist might learn a new melody more easily than ... engineers from the Center for the Neural Basis of ... and Carnegie Mellon Universityhave discovered a fundamental constraint in ... as the cover story in the Aug. 28, 2014, ...
(Date:8/27/2014)... species frequently found in forests has created a thriving ... toads, a new University of Georgia study has found. ... U.S. in the early 1900s, is one of the ... than a dozen states in the past century, particularly ... forests, it can survive in widely diverse ecosystems and ...
(Date:8/27/2014)... DURHAM, N.C. -- When we want to listen carefully ... talking. The second thing we do is stop moving ... unwanted sounds generated by our own movements. , This ... deep in the brain. Indeed, indirect evidence has long ... somehow influences the auditory cortex, which gives rise to ...
Breaking Biology News(10 mins):Pitt and Carnegie Mellon engineers discover why learning can be difficult 2Pitt and Carnegie Mellon engineers discover why learning can be difficult 3More wolf spiders feasting on American toads due to invasive grass, UGA study shows 2More wolf spiders feasting on American toads due to invasive grass, UGA study shows 3Stop and listen: Study shows how movement affects hearing 2Stop and listen: Study shows how movement affects hearing 3
(Date:8/27/2014)... 2014 Reportlinker.com announces that a ... its catalogue: Global Biodegradable Packaging ... http://www.reportlinker.com/p02316661/Global-Biodegradable-Packaging-Materials-Market-2014-2018.html About Biodegradable Packaging ... readily decomposed by the action of microorganisms. ... in terms of raw materials, production technology, ...
(Date:8/27/2014)... One of nature,s mysteries is how plants survive ... in the sun,s rays, while using this energy ... proteins in the plant,s blades quickly dissipate the ... protein quakes. Researchers at DTU Physics have now ... plants, algae and bacteria contain light-absorbing proteins which ...
(Date:8/27/2014)... , Aug. 27, 2014 Reportlinker.com ... available in its catalogue: Global Chelating ... About Chelating Agent A chelating ... covalent bonds with metal ions, thereby forming a ... some metal-ions have on chemical processes, formulations, and ...
(Date:8/27/2014)... ANGELES , Aug. 27, 2014  Lisa Kulik ... years this July 4 holiday, thanks to a groundbreaking ... Ph.D., an internationally renowned clinician-researcher at the University of ... a 55-year-old Peoria, Ariz. resident ... robs its victims of sight. On June 2, she ...
Breaking Biology Technology:Global Biodegradable Packaging Materials Market 2014-2018 2Global Biodegradable Packaging Materials Market 2014-2018 3Global Biodegradable Packaging Materials Market 2014-2018 4Global Biodegradable Packaging Materials Market 2014-2018 5Global Biodegradable Packaging Materials Market 2014-2018 6Global Biodegradable Packaging Materials Market 2014-2018 7DTU researchers film protein quake for the first time 2Global Chelating Agents Market 2014-2018 2Global Chelating Agents Market 2014-2018 3Global Chelating Agents Market 2014-2018 4USC Eye Institute ophthalmologists implant first FDA-approved Argus II retinal prosthesis in western United States 2USC Eye Institute ophthalmologists implant first FDA-approved Argus II retinal prosthesis in western United States 3USC Eye Institute ophthalmologists implant first FDA-approved Argus II retinal prosthesis in western United States 4USC Eye Institute ophthalmologists implant first FDA-approved Argus II retinal prosthesis in western United States 5
Cached News: