Temple virologist receives $6.1 million NIH grant for neuro-AIDS research

Kamel Khalili, Ph.D., director of the Center for Neurovirology and Cancer Biology (CNVCB), has been awarded a $6.1 million grant from the National Institutes of Health for Neuro-AIDS research.

The five-year Program Project (P01) Grant through the National Institute for Neurological Disorders and Stroke, which will support 23 researchers and support staff over three projects, will continue the Center's ongoing investigation into the molecular biology and genetics of the interaction between viruses and host cells in the central nervous system.

"The program is basically an investigation into the neurological problems that are seen in AIDS patients," said Khalili. "We will be looking at HIV's effect on the nervous system to understand the molecular basis for the development and progression of neurological diseases that occur in some AIDS patients."

Khalili, who recently received Temple's Faculty Research Award, said that HIV can trigger the JC virus, which causes the fatal demyelinating disease Progressive Multifocal Leukoencephalopathy (PML), which occurs in some AIDS patients.

The JC virus infects greater than 70 percent of the human population worldwide during early childhood. According to Khalili, the JC virus most likely infects humans through the upper respiratory tract and remains in a latent stage in most people throughout their lives. However, in immunosuppressed individuals such as AIDS patients, the JC virus can become active and lead to the disease PML.

"We're going to investigate the molecular mechanisms that cause reactivation of the JC virus in AIDS patients," he said.

The researchers will be exploring these questions from many angles, several of which are extremely novel, including how the JC virus affects the integrity of the DNA by disregulating the host cell's DNA repair machinery.

"When the integrity of a cell's DNA is compromised, abnormalities such as apoptosis, or cell death, can occur," Khaili said

Contact: Preston M. Moretz
Temple University

Page: 1 2

Related biology news :

1. Third annual Templeton-Cambridge Fellowships awarded to 10 noted journalists
2. John Templeton Foundation awards $2.8 million to examine origins of biological complexity
3. Temple engineers recieve NSF grant to develop interactive high school biology curriculum
4. SHRO signs agreement with Temple to continue biomedical research
5. Temple University researchers develop new targeted cancer therapy
6. Penn virologist edits comprehensive book on Epstein-Barr virus
7. CU virologist finds contagious equine flu in dogs
8. Carnegie Mellons Peter Adams receives EPA research grant
9. Philadelphia ecologist receives top Mongolia honor
10. VIB scientist receives major research grant
11. Maynard Olson receives $500,000 Gruber Genetics Prize

Post Your Comments:

(Date:6/25/2020)... MANSFIELD, Mass. (PRWEB) , ... June 24, 2020 ... ... provider of cloud-based enterprise software and software-driven clinical data services that accelerate drug ... trials for low-dose selinexor, an XPO1 inhibitor, in hospitalized patients with severe COVID-19. ...
(Date:6/23/2020)... ... June 23, 2020 , ... First ... Renovagen Ltd, a UK supplier and manufacturer of innovative portable renewable energy equipment, ... in the fight against the COVID-19 pandemic in Zambia. , One of Renovagen’s ...
(Date:6/23/2020)... THE WOODLNDS, Texas (PRWEB) , ... June 23, ... ... in X-ray analytical instrumentation, is pleased to announce the next event in a ... of X-ray scattering. , The TOPIQ series of webinars was developed in response ...
Breaking Biology News(10 mins):
(Date:7/18/2020)... ... July 16, 2020 , ... ... aid in the early detection and prevention of high-burden diseases, and Centric Consulting, ... hospitals and healthcare organizations to utilize existing data in order to identify and ...
(Date:7/10/2020)... ... 2020 , ... In most research using the zebrafish model, ... in zebrafish embryos, maintaining optical transparency to facilitate microscopic imaging. Over the past ... the zebrafish model to investigate the causes of leukaemia and its relationship with ...
(Date:7/1/2020)... ... June 29, 2020 , ... ... date growth of 40% in 2020, despite many obstacles created as a result ... to increase revenue for its partnered medical practices and medical manufacturers by expanding ...
(Date:6/28/2020)... (PRWEB) , ... June 25, 2020 , ... ... are racing to develop a vaccine or drug treatment. In an effort to ... has publicly released the world’s largest imaging dataset portraying therapeutic compound effects ...
Breaking Biology Technology:
Cached News: