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Testes to incubate stem cells

Men may cringe at the idea, but sperm-producing stem cells found in testicles could be extracted, grown in the lab, and frozen for future use. A team in the Netherlands has successfully harvested spermatogonial stem cells from cows and cultured them inside mouse testes. The hope is that the same thing could be done for men. "This is a very promising route to help young cancer patients undergoing chemotherapy," Dirk de Rooij of Utrecht University, Netherlands, told participants gathered at the first EuroSTELLS conference in Venice last month.

The research team were delighted to find abundant bovine spermatogonial stem cells thriving in the mouse testes, since they are hard to spot in tissue sections. Once the researchers learned to isolate these elusive sperm-producing cells from bull calfs, they transplanted them into mouse testes. Despite the foreign surroundings, the bovine cells survived for long periods, up to three months, although they failed to fully develop into sperm, said de Rooij.

"Our plan is to develop a culture system for spermatogonial stem cells" de Rooij told conference attendees. Although admitting the leap to humans is considerable, the colonised mouse testes are already providing useful insights.

"We'd like to know how to culture human spermatogenic stem cells to restore male fertility after cancer therapy," says Hannu Sariola, from the University of Helsinki in Finland who is also working towards a similar goal.

Bizarrely, a brain cell growth factor also has a powerful influence on spermatogonial stem cells. Glial cell derived neurotrophic factor (GDNF) is also involved in spermatogenesis: levels are high during the neonatal period and drop in adulthood. Indeed, mice that have been genetically manipulated to express high levels of GDNF in the testes produce huge clusters of spermatogonial stem cells. But the risk of cancer is boosted too, so it is not just about turning on the GDNF tap indiscriminately. It m
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Contact: Jens Persson
jpersson@esf.org
33-388-762-158
European Science Foundation
24-Apr-2006


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