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Testosterone replacement therapy: How safe for aging men?

Austin, TX For decades, older women have taken hormone replacements to replenish estrogen and progesterone levels lost to aging. More recently, testosterone (the most important male hormone) supplements have been used by aging men to improve their muscle mass, bone strength, libido and quality of life. In 2002, the number of elderly American men taking testosterone replacement therapy was nearly 819,000, and the number is growing. The increased use has occurred despite the fact that the cardiovascular effects of chronic testosterone treatment in aging males are largely unknown, and the safety of testosterone replacement has not been evaluated.

A team of researchers has been using an animal model to investigate potential links between testosterone supplements and cardiovascular and renal disease. The team, comprised of Radu Iliescu, Licy L. Yanes, Julio C. Sartori-Valinotti, and Jane F. Reckelhoff, is affiliated with the University of Mississippi Medical Centers Department of Physiology and Biophysics, Jackson, MS. Their most recent study and an overview of data from other human and animal studies is part of the upcoming conference, Sex and Gender in Cardiovascular-Renal Physiology and Pathophysiology. The meeting, sponsored by The American Physiological Society (APS; www.The-APS.org), is being held August 9-12, 2007 at the Hyatt Regency Austin on Town Lake, Austin, TX.

Latest Study

The team is presenting its work entitled, Testosterone Supplements Promote Renal Injury and Exacerbate Hypertension in Aging Spontaneously Hypertensive Rats (SHR), in which spontaneously hypertensive rats were used as a model for genetic hypertension.

Three groups of rats were used: intact, gonadectomized (at eight months of age), and testosterone-supplemented rats. Testosterone supplements were administered chronically via pellets and rats were monitored until 13 months of age. Blood pressure was mea
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Contact: Donna Krupa
dkrupa@the-aps.org
301-634-7209
American Physiological Society
8-Aug-2007


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