The Louis-Jeantet-Prize for Medicine encourages further projects of excellence in the prize-winners' laboratories. Alan HALL receives the prize for pioneering work on the regulation of cytoskeleton dynamics in cell adhesion, migration and polarity. With the prize, Alan Hall will further investigate the role of certain enzymes, known as small GTPases and guanine nucleotide exchange factors, in relation to the cytoskeleton, as they may play an important role in metastatic tumour cell invasion. Svante Pääbo receives the prize for his innovative research on the evolution of the human genome in comparison to that of other primates. With the prize, Svante Pääbo wants to identify genes involved in traits that are unique to humans such as speech and language faculties or other cognitive functions. He will investigate the role of these genes in mice. THE Louis-Jeantet Foundation for Medicine awards the two prize-winners a cumulative sum of 0.8 million Euros to carry out their new research projects. In addition each prize-winner receives a personal award of 75,000 Euros. The ceremony to present the prize will take place in Geneva (Switzerland), on Friday April 22nd, 2005. Professor Alan Hall

Alan Hall is a professor of molecular biology and the director of the Medical Research Council Laboratory for Molecular Cell Biology & Cell Biology Unit at the University College London. Alan Hall is a British citizen. He was born in 1952.

The cytoskeleton, composed of actin and myosin, is important for epithelial cells to adopt the correct polarity and to organize cell-cell junctions that attach them firmly to neighbouring cells so that they form a cell layer. The cytoskeleton is also profoundly rearranged when cells migrate. Alan Hall receives the Louis-Jeantet Prize for his discovery that specific enzymes, small GTPases known as Rho and Rac, locally modify the assembly of the cytoskeleton and thereby control both cell-cell adhesion and cell migrati
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Contact: Prof. Svante Pbo
paabo@eva.mpg.de
49-341-355-0500
Max-Planck-Gesellschaft
11-Jan-2005

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