The Molecular Profiling Institute, Inc. launches MammaPrint for breast cancer patients

Phoenix, AZ April 21, 2005 - The Molecular Profiling Institute, Inc. (MPI) announced today that it is now providing the MammaPrint breast cancer test to breast cancer patients in the United States. This is the first commercially available microarray cancer diagnostic that analyzes patients' breast tumors for their individual DNA expression profile.

"MammaPrint more accurately distinguishes between lymph node-negative breast cancer patients who would benefit from additional therapy from those who would not, helping oncologists offer more effective therapy to their patients. Personalized medicine is here," said Dr. Robert Penny, the President and CEO of MPI.

According to the National Cancer Institute of the National Institutes of Health (NIH)(1) and the American Cancer Society(2), 216,000 new cases of breast cancer are found annually in the United States of which 56% or 121,000 are lymph node negative and 20% of these or 24,200 will develop distant metastases and require follow on treatment.(3) However, in node-negative women under 51 years of age, 45% are treated with chemotherapy in the United States today, meaning over twice as many patients are currently treated than may actually need the therapy.(4) Additionally, of patients in the category that could benefit from treatment, a large portion are never started on therapy or receive sub-therapeutic doses.(5)

"Existing methods can't distinguish the patients with a high risk for recurrence from those with low risk with comparable accuracy," said Dr. David Alberts, Director of the Arizona Cancer Center. Currently, one of the most important prognostic indicators for the cancer recurring is the size of the tumor. However, a significant number of tumors less than one centimeter in diameter are actually high risk.

The 70 genes in a woman's tumor analyzed by MammaPrint predict the 10-year survival of the patient at a significance level over three times greater than existing m

Contact: David Mallery
The Translational Genomics Research Institute

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