The Molecular Profiling Institute named US provider of genetic breast cancer test

Phoenix, AZ, December 8, 2004--The Molecular Profiling Institute (MPI), today announced that it is the sole source provider in the United States for MammaPrint. MammaPrint is a prognostic test developed by Agendia that helps identify how a breast cancer patient's tumor will behave. MPI in collaboration with the Netherlands-based Agendia, and AmeriPath will offer MammaPrint through physician referral to breast cancer patients nationwide beginning in January 2005.

MammaPrint employs gene expression profiling to assess the recurrence risk in breast cancer patients. Oncologists receive detailed prognostic information on women with primary invasive breast cancer aged 55 years or younger who are lymph node negative with either a positive or negative estrogen receptor status. Taken together with a patient's clinical information this test may provide valuable assistance for oncologists in formulating tailor-made treatment plans.

Approximately 70 percent of the 250,000 patients diagnosed annually with breast cancer are stage I and II. Nearly 50 percent of affected women are under age 60. The test has the potential to add positively to the clinical decisions influencing nearly 70,000 breast cancer patients per year.

Using the MammaPrint microarray assay, MPI can determine which genes are expressed in a breast cancer patient's tumor. The tumor is then classified as "good" prognosis or "poor" prognosis. The results allow oncologists to implement a more effective and personalized treatment plan.

Typically, oncologists use several clinical factors --age, estrogen receptor status, tumor size and grade-- to determine how a patient's tumor will behave and how best to intervene. When compared to these clinical factors, the MammaPrint test has been shown to provide the most comprehensive prognostic information assessing the development of future metastases.

A patient-tailored treatment plan based on the genetics of the tumor combined with sta

Contact: Galen Perry
The Translational Genomics Research Institute

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