HOME >> BIOLOGY >> NEWS
The biggest isn't always best when it comes to treating cancer

Developing immunotherapeutic approaches to treat individuals with cancer is an area of intensive investigation. One such approach being developed is the generation of cancer vaccines containing peptides that mimic tumor antigens (known as mimotopes) to induce potent tumor-specific T cell responses. However, previous studies have indicated that the magnitude of a tumor antigenspecific T cell response in vitro does not always correlate with tumor regression in vivo.

Now, in a study appearing online on August 24 in advance of publication in the September print issue of the Journal of Clinical Investigation, Jill Slansky and colleagues from the University of Colorado have shown that mice vaccinated with mimotopes that induce in vitro T cell responses of intermediate magnitude are protected against tumor growth. By contrast, mimotopes that induce in vitro T cell responses of high magnitude do not protect mice from tumor growth. Both types of mimotope caused T cells to infiltrate the tumors, but only the T cells activated by mimotopes inducing in vitro T cell responses of intermediate magnitude produced the soluble factor interferon-gamma, which is important for effective tumor-specific T cell responses. This study has important implications for the further development of cancer vaccines containing mimotopes, as many current studies have used the magnitude of a tumor-specific T cell response to identify the best mimotope for the vaccine.


'"/>

Contact: Karen Honey
press_releases@the-jci.org
212-342-4159
Journal of Clinical Investigation
24-Aug-2006


Page: 1

Related biology news :

1. What we can learn from the biggest extinction in the history of Earth
2. Leanest teens are biggest energy users and consumers
3. Polarsterns biggest fish catch in 24 years of research in Antarctic waters
4. The biggest bug in gut discomfort
5. Yale dean addresses biggest environmental threats in new book
6. Greenhouse theory smashed by biggest stone
7. The biggest family tree ever
8. New evidence indicates biggest extinction wasnt caused by asteroid or comet
9. One Wwox isnt enough (to protect against cancer)
10. In stretching, pain doesnt equal gain; but if NO isnt producing, stretching wont help
11. How sweet it isnt -- preference for alternatives to sugar based on sour, bitter tastes

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/3/2017)...  Data captured by IsoCode, IsoPlexis Corporation,s ... statistically significant association between the potency of ... objective response of cancer patients post-treatment. The ... cancer patients will respond to CAR-T cell ... to improve both pre-infusion potency testing and cell ...
(Date:3/30/2017)... YORK , March 30, 2017 Trends, ... type (physiological and behavioral), by technology (fingerprint, AFIS, iris ... voice recognition, and others), by end use industry (government ... and immigration, financial and banking, and others), and by ... Europe , Asia Pacific , ...
(Date:3/27/2017)... N.Y. , March 27, 2017  Catholic ... Information and Management Systems Society (HIMSS) Analytics for ... EMR Adoption Model sm . In addition, CHS ... of U.S. hospitals using an electronic medical record ... for its high level of EMR usage in ...
Breaking Biology News(10 mins):
(Date:8/15/2017)... ... August 15, 2017 , ... JULABO USA introduces its ... new website makes it easy to navigate through the site whether you’re in ... detailed product information, educational industry content and visit the company’s social media accounts, ...
(Date:8/11/2017)... ... 11, 2017 , ... A staple in the community for more than 60 ... key elements including a new digital marketing strategy and updated logo. , As part ... has partnered with the South Texas Blood & Tissue Center for the month of ...
(Date:8/10/2017)... Linda, Ca (PRWEB) , ... August 09, 2017 ... ... exosomes for regenerative medicine applications in the clinic is here. The team at ... EVs present in conditioned medium for clinical studies. , Dr. Travis Antes, ...
(Date:8/10/2017)... ... August 10, 2017 , ... SPIE, the ... Ltd. as its exclusive sales representative for SPIE Journals in Japan. Kinokuniya has ... Digital Library in Japan. , “We look forward to expanding our relationship with ...
Breaking Biology Technology:
Cached News: