HOME >> BIOLOGY >> NEWS
The biggest isn't always best when it comes to treating cancer

Developing immunotherapeutic approaches to treat individuals with cancer is an area of intensive investigation. One such approach being developed is the generation of cancer vaccines containing peptides that mimic tumor antigens (known as mimotopes) to induce potent tumor-specific T cell responses. However, previous studies have indicated that the magnitude of a tumor antigenspecific T cell response in vitro does not always correlate with tumor regression in vivo.

Now, in a study appearing online on August 24 in advance of publication in the September print issue of the Journal of Clinical Investigation, Jill Slansky and colleagues from the University of Colorado have shown that mice vaccinated with mimotopes that induce in vitro T cell responses of intermediate magnitude are protected against tumor growth. By contrast, mimotopes that induce in vitro T cell responses of high magnitude do not protect mice from tumor growth. Both types of mimotope caused T cells to infiltrate the tumors, but only the T cells activated by mimotopes inducing in vitro T cell responses of intermediate magnitude produced the soluble factor interferon-gamma, which is important for effective tumor-specific T cell responses. This study has important implications for the further development of cancer vaccines containing mimotopes, as many current studies have used the magnitude of a tumor-specific T cell response to identify the best mimotope for the vaccine.


'"/>

Contact: Karen Honey
press_releases@the-jci.org
212-342-4159
Journal of Clinical Investigation
24-Aug-2006


Page: 1

Related biology news :

1. What we can learn from the biggest extinction in the history of Earth
2. Leanest teens are biggest energy users and consumers
3. Polarsterns biggest fish catch in 24 years of research in Antarctic waters
4. The biggest bug in gut discomfort
5. Yale dean addresses biggest environmental threats in new book
6. Greenhouse theory smashed by biggest stone
7. The biggest family tree ever
8. New evidence indicates biggest extinction wasnt caused by asteroid or comet
9. One Wwox isnt enough (to protect against cancer)
10. In stretching, pain doesnt equal gain; but if NO isnt producing, stretching wont help
11. How sweet it isnt -- preference for alternatives to sugar based on sour, bitter tastes

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:11/19/2019)... ... November 19, 2019 , ... Project Lifeline – a community partnership ... to address substance use disorder (SUD) – will take center stage at ... to the program’s effectiveness in preventing and treating opioid abuse in Blair County, Pennsylvania, ...
(Date:11/14/2019)... ... November 13, 2019 , ... NDA Partners Chairman ... a regulatory affairs and program management executive with more than 33 years of ... joined the firm as an Expert Consultant. , Robert Peterson has extensive ...
(Date:11/12/2019)... ... 12, 2019 , ... G5, the leader in real estate ... to 25% and reduces cost-per-click by as much as 15%. An integral part ... to predict best advertising outcomes and automatically allocate daily ad investments across the ...
Breaking Biology News(10 mins):
(Date:11/27/2019)... ... November 25, 2019 , ... Silony Medical, ... first robotic-assisted and navigated surgery in the UK. The procedure was performed in ... surgeons, Dr. Syed Aftab and Dr. Alexander Montgomery. The surgery, which took place ...
(Date:11/22/2019)... ... , ... Lajollacooks4u is preparing for another busy holiday season. Not only ... its popular cooking classes and team-building events, but the company has also booked numerous ... been a favorite for companies of all sizes since 2008. Each event is ...
(Date:11/19/2019)... ... , ... Supercomputing Conference – Cirrascale Cloud Services® , ... Vehicle , Medical Imaging, and Natural Language Processing (NLP) workflows, today announced it ... stack as part of its bare-metal cloud service offerings. In addition to offering ...
(Date:11/12/2019)... ... November 12, 2019 , ... ... biopharmaceutical R&D, today announced that Immatics Biotechnologies , a clinical-stage biopharmaceutical ... to streamline their R&D operations related to the discovery and development ...
Breaking Biology Technology:
Cached News: