HOME >> BIOLOGY >> NEWS
The closest look ever at the cell's machines

Today researchers in Germany announce they have finished the first complete analysis of the "molecular machines" in one of biology's most important model organisms: S. cerevisiae (baker's yeast). The study from the biotechnology company Cellzome, in collaboration with the European Molecular Biology Laboratory (EMBL), appears in this week's online edition of Nature.

"To carry out their tasks, most proteins work in dynamic complexes that may contain dozens of molecules," says Giulio Superti-Furga, who launched the large-scale project at Cellzome four years ago. "If you think of the cell as a factory floor, up to now, we've known some of the components of a fraction of the machines. That has seriously limited what we know about how cells work. This study gives us a nearly complete parts list of all the machines, and it goes beyond that to tell us how they populate the cell and partition tasks among themselves."

The study combined a method of extracting complete protein complexes from cells (tandem affinity purification, developed in 2001 by Bertrand Sraphin at EMBL), mass spectrometry and bioinformatics to investigate the entire protein household of yeast, turning up 257 machines that had never been observed. It also revealed new components of nearly every complex already known.

In the course of the work, new computational techniques were developed at EMBL that gave new insights into the dynamic nature of protein complexes. In contrast to most man-made factories, cells continually dismantle and reassemble their machines at different stages of the cell cycle and in response to environmental challenges, such as infections.

"This would be a logistical nightmare if the cell had to build every machine from scratch any time it needed to do something," says Anne-Claude Gavin, former Director of Molecular and Cell Biology at Cellzome and currently a team leader at EMBL. "We've discovered that the reality is different. Cells use a mixed strateg
'"/>

Contact: Anna-Lynn Wegener
wegener@embl.de
496-221-387-8452
European Molecular Biology Laboratory
22-Jan-2006


Page: 1 2 3

Related biology news :

1. Scientists find missing link between whale and its closest relative, the hippo
2. New fossil may be closest yet to ancestor of all great apes
3. Loss of cells antenna linked to cancers development
4. Surprising origin of cells internal highways
5. Columbia scientists determine 3-dimensional structure of cells fuel gauge
6. Defective movement of cells power plants implicated in commom inherited neurological disorder
7. Johns Hopkins researchers find link between cells energy use and genome health
8. Hopkins researchers discover genetic switch that turns off an oxygen-poor cells combustion engine
9. New and sharper X-rays of cells ribosome could lead to better antibiotics
10. Scientists discover secret behind human red blood cells amazing flexibility
11. UCSB researchers discover that the cells endosomes use a surprising transportation system

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: The closest look ever the cell machines

(Date:6/16/2015)... NEW YORK , June 16, 2015  With ... the world, security remains a top concern. The recent ... confirms the need for strong authentication within government ... HYPR Token, a biometric one-time password (OTP) authenticator, has ... Processing Standards (FIPS) 140-2 Level 3 validation for tamper ...
(Date:6/16/2015)... -- Fingerprint Cards (FPC) raises the revenue guidance ... to at least 340 MSEK to that it will amount ... market growth and orders received the revenue guidance for 2015 ... 2015 will exceed 1,500 MSEK to an updated guidance that ... Due to receipt of orders of touch fingerprint sensors ...
(Date:6/15/2015)... A new report [ 1 ] ... consumers using mobile banking applications want their mobile devices to ... instead of having to prove who they are with passwords ...   -   The Fusion of Financial Services, Mobile and ... channel used by Gen X and Gen Y to access ...
Breaking Biology News(10 mins):Government Ready Biometric Security Approaching as HYPR Corp. Files FIPS 140-2 Level 3 Validation for Its Proprietary Biometric Token 2Government Ready Biometric Security Approaching as HYPR Corp. Files FIPS 140-2 Level 3 Validation for Its Proprietary Biometric Token 3Fingerprint Cards Raises the Revenue Guidance for Q2 2015 and for the Full Year 2015 2Fingerprint Cards Raises the Revenue Guidance for Q2 2015 and for the Full Year 2015 3One in Four US Consumers Would Share Their DNA With Their Bank to Secure Financial and Personal Information, Telstra Report Finds 2One in Four US Consumers Would Share Their DNA With Their Bank to Secure Financial and Personal Information, Telstra Report Finds 3One in Four US Consumers Would Share Their DNA With Their Bank to Secure Financial and Personal Information, Telstra Report Finds 4
(Date:6/30/2015)... HAUPPAUGE, N.Y. , June 30, 2015  Custom ... provider, announced today that they are silver sponsors of ... an official PCDC sponsor, Custom is lending their support ... in low-income communities. Since its founding in ... for the primary care area.  PCDC has financed over ...
(Date:6/30/2015)... -- The Dr. Samadi Prostate Cancer Center in New ... of new genetic testing methods for men with an elevated ... Dr. Samadi,s Prostate Cancer Center ... risk and optimizing the diagnosis of prostate cancer, both pre-biopsy ... offer these revolutionary genetic tests to men with an elevated ...
(Date:6/30/2015)... ... June 30, 2015 , ... Smarter Alloys today announced a ... archwire that allows orthodontists to simultaneously apply different forces to different teeth. The ... “We’re thrilled about taking SmartArch one step closer to commercial availability for orthodontists ...
(Date:6/29/2015)... ... ... This cutting edge standard making is a madatory tool for use in high-end ... the world’s first cuvette-shaped, solid-state filter that lets metrologists and quality control personnel know ... standards, such as those made from didymium glass were only able to operate up ...
Breaking Biology Technology:Custom Computer Specialists Announces Sponsorship Of The Primary Care Development Corporation's Corporate Circle 2New Revolutionary Genetic Testing for Prostate Cancer Offered at Dr. Samadi's Prostate Cancer Center 2New Revolutionary Genetic Testing for Prostate Cancer Offered at Dr. Samadi's Prostate Cancer Center 3New Revolutionary Genetic Testing for Prostate Cancer Offered at Dr. Samadi's Prostate Cancer Center 4New Revolutionary Genetic Testing for Prostate Cancer Offered at Dr. Samadi's Prostate Cancer Center 5New case studies for SmartArch orthodontic archwire paves way to product launch later this year 2FireflySci Releases Spectrophotometer Calibration Standards for NIR Wavelength Accuracy Verification 2FireflySci Releases Spectrophotometer Calibration Standards for NIR Wavelength Accuracy Verification 3
Cached News: