HOME >> BIOLOGY >> NEWS
The closest look ever at the cell's machines

Today researchers in Germany announce they have finished the first complete analysis of the "molecular machines" in one of biology's most important model organisms: S. cerevisiae (baker's yeast). The study from the biotechnology company Cellzome, in collaboration with the European Molecular Biology Laboratory (EMBL), appears in this week's online edition of Nature.

"To carry out their tasks, most proteins work in dynamic complexes that may contain dozens of molecules," says Giulio Superti-Furga, who launched the large-scale project at Cellzome four years ago. "If you think of the cell as a factory floor, up to now, we've known some of the components of a fraction of the machines. That has seriously limited what we know about how cells work. This study gives us a nearly complete parts list of all the machines, and it goes beyond that to tell us how they populate the cell and partition tasks among themselves."

The study combined a method of extracting complete protein complexes from cells (tandem affinity purification, developed in 2001 by Bertrand Sraphin at EMBL), mass spectrometry and bioinformatics to investigate the entire protein household of yeast, turning up 257 machines that had never been observed. It also revealed new components of nearly every complex already known.

In the course of the work, new computational techniques were developed at EMBL that gave new insights into the dynamic nature of protein complexes. In contrast to most man-made factories, cells continually dismantle and reassemble their machines at different stages of the cell cycle and in response to environmental challenges, such as infections.

"This would be a logistical nightmare if the cell had to build every machine from scratch any time it needed to do something," says Anne-Claude Gavin, former Director of Molecular and Cell Biology at Cellzome and currently a team leader at EMBL. "We've discovered that the reality is different. Cells use a mixed strateg
'"/>

Contact: Anna-Lynn Wegener
wegener@embl.de
496-221-387-8452
European Molecular Biology Laboratory
22-Jan-2006


Page: 1 2 3

Related biology news :

1. Scientists find missing link between whale and its closest relative, the hippo
2. New fossil may be closest yet to ancestor of all great apes
3. Loss of cells antenna linked to cancers development
4. Surprising origin of cells internal highways
5. Columbia scientists determine 3-dimensional structure of cells fuel gauge
6. Defective movement of cells power plants implicated in commom inherited neurological disorder
7. Johns Hopkins researchers find link between cells energy use and genome health
8. Hopkins researchers discover genetic switch that turns off an oxygen-poor cells combustion engine
9. New and sharper X-rays of cells ribosome could lead to better antibiotics
10. Scientists discover secret behind human red blood cells amazing flexibility
11. UCSB researchers discover that the cells endosomes use a surprising transportation system

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: The closest look ever the cell machines

(Date:8/4/2015)... 04, 2015 ... announced the addition of the "Digital ... Service), Sub-Segment (Computer Forensics, Network Forensics, Mobile ... Service, Vertical and Region - Global Forecast ... By Component (Hardware, Software, and ...
(Date:8/4/2015)... N.Y., Aug. 4, 2015  AMRI (NASDAQ: AMRI ) today ... 30, 2015. Highlights: , Second quarter contract ... from 2014 , Adjusted contract margins of ... of $0.22, including a $0.05 decrease in EPS from royalties in ... $16 million "We are very pleased to present ...
(Date:8/3/2015)... Aug. 3, 2015 Synaptics, Inc. (Nasdaq: ... today announced that members of the executive management team ... Crest Global Technology Leadership Forum on Tuesday, August 11, ... be held at the Sonnenalp Resort in ... may include forward-looking information. An audio webcast of the ...
Breaking Biology News(10 mins):Digital Forensics Market - The Market Represents a Compound Annual Growth Rate (CAGR) of 11.3% From 2015 to 2020 2AMRI Announces Second Quarter 2015 Results 2AMRI Announces Second Quarter 2015 Results 3AMRI Announces Second Quarter 2015 Results 4AMRI Announces Second Quarter 2015 Results 5AMRI Announces Second Quarter 2015 Results 6AMRI Announces Second Quarter 2015 Results 7AMRI Announces Second Quarter 2015 Results 8AMRI Announces Second Quarter 2015 Results 9AMRI Announces Second Quarter 2015 Results 10AMRI Announces Second Quarter 2015 Results 11AMRI Announces Second Quarter 2015 Results 12AMRI Announces Second Quarter 2015 Results 13AMRI Announces Second Quarter 2015 Results 14AMRI Announces Second Quarter 2015 Results 15AMRI Announces Second Quarter 2015 Results 16AMRI Announces Second Quarter 2015 Results 17AMRI Announces Second Quarter 2015 Results 18AMRI Announces Second Quarter 2015 Results 19AMRI Announces Second Quarter 2015 Results 20AMRI Announces Second Quarter 2015 Results 21AMRI Announces Second Quarter 2015 Results 22AMRI Announces Second Quarter 2015 Results 23AMRI Announces Second Quarter 2015 Results 24
(Date:8/5/2015)... ... August 05, 2015 , ... ... transition from legacy tubes, with 2D barcode labels on the lid, to modern ... tube 2D barcodes in 1 second, using FluidX’s IntelliCode software, which deals easily ...
(Date:8/5/2015)... ... August 05, 2015 , ... MTI-GlobalStem, ... the launch of an updated corporate identity, including new company name, logo and ... in 2009. The company moved into a new, joint facility in 2014 to ...
(Date:8/4/2015)... ... 05, 2015 , ... Spirax Sarco , Inc. has ... The handbook provides a complete range of information needed to evaluate and ... product offering into an easy-to-navigate single edition,” says Dawn Dukes, Public Relations & ...
(Date:8/4/2015)... BIOA ), a leader in renewable materials today ... 30, 2015. Highlights included: , The Sarnia plant achieved ... cost of the Sarnia plant is projected to be ... of the estimate communicated at the onset of the ... announced commercial collaborations in two targeted industry segments; with ...
Breaking Biology Technology:RURO Announces FreezerPro® 7 Integration with Top-down 2D barcode scanners by FluidX 2MTI-GlobalStem Announces Updated Company Identity and Website 2MTI-GlobalStem Announces Updated Company Identity and Website 3Spirax Sarco releases Product Handbook 2BioAmber Reports Second Quarter 2015 Financial Results 2BioAmber Reports Second Quarter 2015 Financial Results 3BioAmber Reports Second Quarter 2015 Financial Results 4BioAmber Reports Second Quarter 2015 Financial Results 5BioAmber Reports Second Quarter 2015 Financial Results 6BioAmber Reports Second Quarter 2015 Financial Results 7BioAmber Reports Second Quarter 2015 Financial Results 8BioAmber Reports Second Quarter 2015 Financial Results 9BioAmber Reports Second Quarter 2015 Financial Results 10BioAmber Reports Second Quarter 2015 Financial Results 11BioAmber Reports Second Quarter 2015 Financial Results 12
Cached News: