HOME >> BIOLOGY >> NEWS
The fat connection

One out of 12 people in the western world suffers from type 2 (adult onset) diabetes. Worldwide, 150 million people are diabetic and their numbers are expected to double in the next 20 years, a result of the growing obesity epidemic. Yet, the reasons for the strong correlation between excess body fat and diabetes have been puzzling researchers. Scientists at the Weizmann Institute of Science and the University of Umea, Sweden, have now unraveled a mechanism by which fat contributes to the onset of the disease. Their results were published in the April issue of Cell Metabolism.

Type 2 diabetes is a complex disease characterized by the body's inability to efficiently utilize sugar. Two stages of the disease have been identified: In the first, "silent" stage, the body's cells lose their ability to respond properly to the crucial hormone insulin, which is responsible for moving sugar from the blood into cells. If sugar remains in the bloodstream, the insulin-producing beta cells in the pancreas compensate by stepping up production. Eventually this leads to beta cell exhaustion, reduced insulin output and the appearance of full-blown diabetes.

Elevated fat in the bloodstream appears to accelerate both stages of the disease; but exactly how does this happen? The culprit may be a receptor known as GPR40 found on the outer surface of pancreatic beta cells. GPR40 was recently discovered to respond to fatty acids, alerting beta cells to their presence in the bloodstream. Beta cells were known to be attuned to changes in blood glucose levels, responding to after-meal glucose surges with a sharp increase in insulin production. But when fat is present in addition to sugar, the GPR40 receptor causes even greater insulin output. Frequent overstimulation of the beta cells may be tied to persistently elevated insulin levels, hastening the onset of the disease.

How does this destructive cycle begin? To understand GPR40's role, Prof. Michael Walker and students
'"/>

Contact: Alex Smith
asmith@jgordonassociates.com
212-367-3892
American Committee for the Weizmann Institute of Science
16-May-2005


Page: 1 2

Related biology news :

1. Strength of connections between brain regions may affect an adolescents response to peer influence
2. The kapok connection -- Study explains rainforest similarities
3. ASU research shows connection between testosterone, dietary antioxidants and bird coloration
4. New role for sugars: Research shows connections between sugar modifications in cells and cancer
5. Researchers discover connection between allergic diseases and autoimmune diseases
6. With fruit fly sex, researchers find mind-body connection
7. Nerve fibers need specific growth factor chemical to form connections within the brain
8. UCSD scientists establish connection between life today and ancient changes in ocean chemistry
9. Age-related changes in DNA repair illuminate the connection between age and genetic damage
10. Scientists get best look ever at water-life connection
11. On the track of tiny larvae, a new model elucidates connections in marine ecology

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: The fat connection

(Date:3/23/2015)... , Mar. 23, 2015 NXT-ID, Inc. (NASDAQ: NXTD ... on the growing mobile commerce market, announces its biometric payment ... campaign on CNBC television starting March 30 th . ... airing in New York markets. ... "We are excited about our new ad campaign following the ...
(Date:3/19/2015)... Inc. (NASDAQ: NXTD ) ("NXT-ID" or the "Company"), ... market, announces its biometric payment technology, the Wocket® smart wallet ... on Washington DC,s Fox 5 News ... Next Great Thing", host Laura Evans calls the ... really big breakthrough in mobile payment.,  Award-winning ...
(Date:3/16/2015)... HANOVER, Germany , March 16, 2015 /PRNewswire/ ... DERMALOG Identification Systems GmbH will present groundbreaking innovations ... Hanover, Germany . ... DERMALOG,s latest biometric innovation is well at ... the next generation e-gate made in ...
Breaking Biology News(10 mins):NXT-ID's Wocket Smart Wallet to Launch New CNBC Regional TV Ad Campaign 2NXT-ID's Wocket Smart Wallet to Launch New CNBC Regional TV Ad Campaign 3NXT-ID's Wocket Smart Wallet Featured on Fox News Segment, "The Next Great Thing" 2NXT-ID's Wocket Smart Wallet Featured on Fox News Segment, "The Next Great Thing" 3DERMALOG Presents its Latest Biometric Innovations at the Hannover CeBIT Exhibition, 16 - 20 March 2015 2DERMALOG Presents its Latest Biometric Innovations at the Hannover CeBIT Exhibition, 16 - 20 March 2015 3
(Date:3/31/2015)... FRANCISCO , March 31, 2015  Sonoa Health, ... Australia , has developed a world-first consumer health ... records, medication prescriptions, wearable devices and more. ... Stewart as its CEO, who brings to the ... corporate advisory, which has included working closely with the ...
(Date:3/31/2015)... DALLAS and NEW YORK ... Inc. (NASDAQ: PTBI ), a biopharmaceutical company ... products, announced today that its Korean marketing partner, ... received marketing approval in Korea from the country,s ... the Korea Testing & Research Institute (KTR) for ...
(Date:3/31/2015)... 31, 2015 Diasome Pharmaceuticals, Inc. ( ... Inc., that a United States patent has recently been ... , Entitled “Lipid Construct for Delivery of ... matter claims related to the use of Diasome’s proprietary ... injected insulin to more effectively reach the liver’s metabolic ...
(Date:3/30/2015)... , March 30, 2015  Multiple new research abstracts ... several important health factors. From their impact on colon ... positive effect on both gut health and vascular health, ... detail our latest understanding of walnuts, inner workings. Running ... , this annual meeting attracts an international audience ...
Breaking Biology Technology:Investment Banker Appointed CEO of Australian Health Tech Start-Up 2Investment Banker Appointed CEO of Australian Health Tech Start-Up 3PlasmaTech Biopharmaceuticals' Partner Hanmi Pharmaceuticals Receives Marketing Approval For MuGard In Korea 2PlasmaTech Biopharmaceuticals' Partner Hanmi Pharmaceuticals Receives Marketing Approval For MuGard In Korea 3Diasome Pharmaceuticals, Inc. Announces Notice of Allowance from US PTO for Liver Targeting System for Insulin 2New Findings Support the Benefits of Eating Walnuts on Overall Health 2New Findings Support the Benefits of Eating Walnuts on Overall Health 3New Findings Support the Benefits of Eating Walnuts on Overall Health 4
Cached News: