HOME >> BIOLOGY >> NEWS
The 'female advantage' in kidney disease does not extend to diabetic women

en with diabetes are more likely to get kidney disease than their non-diabetic female counterparts, the Georgetown researchers conducted several studies in which they determined that:

  • diabetes is associated with reduced estrogen (estradiol) levels, which may explain why the females lose the protective factor when it comes to diabetes

  • estrogen and estrogen-like supplements protect the kidney in an animal model of diabetic renal disease, suggesting that restoring estrogen levels provides protection against kidney disease

  • the absence of the hormone testosterone contributes to a more rapid progression of kidney disease when diabetes is present. More severe renal damage can be found when diabetes is present.

Conclusion

These findings suggest that sex hormones play a significant role in the development of diabetic kidney disease. According to Maric, "Our observations suggest that kidney disease in diabetic women may not be the result of absolute levels of hormones, as previously thought, but to the relative ratio of [sex hormone] androgen to estrogen. It may well be that the ratio of the two hormones is what determines the effect of the hormones in the diabetic kidney."

According to Dr. Maric, "The biggest surprise has been the finding that sex hormones -- normally thought to control only the reproductive function -- are involved in controlling processes in non-reproductive organs, including the kidney. Moving forward, we need to look more deeply into understanding how sex hormones affect organ function in each gender."


'"/>

Contact: Donna Krupa
dkrupa@the-aps.org
301-634-7209
American Physiological Society
8-Aug-2007


Page: 1 2

Related biology news :

1. A gene that protects from kidney disease
2. Chinese medicinal compound stops formation of cysts in polycystic kidney disease in lab
3. Adult stem/progenitor cells repair of damaged brain, pancreas, kidney cells newly understood
4. New reference material for diagnosing kidney disease
5. Triptolide: A potential drug for polycystic kidney disease
6. Nicotine: The link between cigarette smoking and kidney disease progression?
7. Proteins effects essential for kidney-to-bladder urine transfer
8. UVA receives training grant for new kidney disease researchers
9. Mutant gene causes severe kidney disease in infants
10. Convening kidney health in Copenhagen
11. Treatment disconnect in kidney cancer: Rising mortality despite more small tumors, more surgery

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: The female advantage kidney disease does not extend diabetic women

(Date:7/25/2014)... puberty is influenced by ,imprinted genes,a subset of genes whose ... This is the first evidence that imprinted genes can control ... study were published today in the journal Nature . ... a marker for the timing of puberty in females. ... girls, is an inherited trait, and is linked to breast ...
(Date:7/24/2014)... (July 24, 2014) Scientists at The New ... one step closer to creating a viable cell ... own cells. , For the first time, ... lines from skin samples of patients with primary ... accelerated protocol to induce these stem cells into ...
(Date:7/24/2014)... species for food or commercial food sale, has been ... decline of many species of primates and other mammals. ... half of the species being consumed are birds, particularly ... only the meat made available for sale but the ... hunters and brought to villages for consumption, we noted ...
Breaking Biology News(10 mins):Could age of first period influence development of diseases in older women? 2NYSCF scientists one step closer to cell therapy for multiple sclerosis patients 2
(Date:7/24/2014)... Engineering at the University of Delaware, is known ... energy engineering, environmental sustainability and electronics. , His ... with a well-defined, crystalline structure. At the atomic ... that zeolites can separate molecules with size differences ... of a nanometer), making them useful to the ...
(Date:7/24/2014)... (PRWEB) July 24, 2014 Your ... advances in modeling lithium-ion battery storage capacity. , ... from a theoretical model created at Lawrence ... that predicts how carbon components will perform ... storage emphasizes the urgent need for higher-performance batteries. ...
(Date:7/24/2014)... 2014 2014 Deep Research Report ... a professional and in-depth research report on Potassium ... basic information, including its definition, classification, application, ... research covers the international market analysis, including China’s ... covering macroeconomic environment & economic situation analysis, the ...
(Date:7/24/2014)... The first part of the session ... in Human Studies” will cover comprehensive clinical support in ... With increasing R&D costs and declining industry success in ... the knowledge collected in early Phase I/IIa study data ... late stage development. , Next, the presenters will examine ...
Breaking Biology Technology:University of Delaware researcher describes new approach for creating organic zeolites 2Getting More Life out of Lithium-ion Batteries 2Potassium Sulphate Market & SHMP Industry 2014 (Global, China) Analysis Now Available at DeepResearchReports.com 2Potassium Sulphate Market & SHMP Industry 2014 (Global, China) Analysis Now Available at DeepResearchReports.com 3Potassium Sulphate Market & SHMP Industry 2014 (Global, China) Analysis Now Available at DeepResearchReports.com 4Best Practices for Optimizing Dose Escalation in First in Human Studies, New Webinar August 6th Hosted by Xtalks 2
Cached News: