HOME >> BIOLOGY >> NEWS
The new form of trypanosomiasis discovered in India stems from a deficiency in apolipoproteinL-1

The two known types of human trypanosomiasis, endemic in two regions of the world, are sleeping sickness in Africa, caused by the parasites Trypanosoma brucei gambiense or T. b. rhodiense, and Chagas' disease in South America induced by T. cruzi. Everywhere else, normally only animals are infected by trypanosomes that, although specific for humans are not pathogenic for them. Yet, in 2004, the first case of human trypanosomiasis was formally identified in India by IRD researcher Philippe Truc, working with the WHO and the Maharashtra State Department of Health (1). The patient was a farmer living in this State who proved to be infected by a trypanosome, T. evansi, usually a parasite of camels and cattle. In South America, North Africa and in a great part of Asia including India, where this parasite is present, many human populations are currently living in contact with infected animals. Scientists from the Universit Libre de Bruxelles , in conjunction with Philippe Truc and Indian medical specialists, under an agreement with WHO (2), carried out analyses on blood serum from the infected patient, which led them to identify the cause of this first case of human trypanosomiasis in India.

Humans possess natural resistance to this parasite, as they have towards related African trypanosomes, like T. brucei. In the latter case, the innate immunity results from the trypanolytic activity of a specific human protein, apolipoprotein L-1 (APOL-1). Once absorbed inside the parasite, this protein forms pores in the parasite's organelle membrane, thus inducing the destruction of the trypanosome. However, the two subspecies T. brucei rhodesiense and T. b. gambiense have, with time, overcome human immune defences by acquiring resistance to APOL-1 and thereby causing sleeping sickness in Africa. In T. b. rhodesiense, this resistance mechanism involves a protein that is peculiar to this subspecies, named SRA (Serum Resistance-associated protein), which interacts strongl
'"/>

Contact: Marie Guillaume-Signoret
fichesactu@paris.ird.fr
33-014-803-7607
Institut de Recherche Pour le Dveloppement
19-Jan-2007


Page: 1 2 3

Related biology news :

1. New, more direct pathways from outside the cell-to-cell nuclei discovered
2. A new brake on cellular energy production discovered
3. New target for HIV/AIDS drugs and vaccine discovered
4. Surprising new species of light-harvesting bacterium discovered in Yellowstone
5. Scratch no more: Gene for itch sensation discovered
6. Fruit fly gene from out of nowhere is discovered
7. A novel molecular dictator with a conscience discovered
8. Gene discovered for type 1 diabetes in children
9. Alzheimers prevention role discovered for prions
10. Link between obesity and enlarged heart discovered by University of Arizona researchers
11. Genetic fellow traveler discovered in Alzheimers

Post Your Comments:
(Date:11/5/2014)... de Janeiro, Brazil -Individuals show great diversity in their ... males and females greatly differ in their perceptual evaluation ... of smell tests. , Sex differences in ... behaviors and may be connected to one,s perception of ... emotions. Thus, women,s olfactory superiority has been suggested to ...
(Date:11/4/2014)... right amount of death at the right time might ... new research that could help in understanding animal populations, ... In a paper in the journal Trends in ... European colleagues conclude that the kind of positive population ... individuals, or mortality, depends on the size and developmental ...
(Date:11/4/2014)... 2014) — Think about the way our bodies are ... cells know that they are supposed to become a ... tissues find the correct place and alignment? Researchers at ... questions. , In a new study, UM researchers describe ... their surrounding neighbors, at the head-trunk region. Their discovery ...
Breaking Biology News(10 mins):The female nose always knows: Do women have more olfactory neurons? 2When less is more: Death in moderation boosts population density in nature 2The inside story: How the brain and skull stay together 2
(Date:11/26/2014)... ADDISON, TX (PRWEB) November 25, 2014 ... age-defying skincare products, earned three prestigious MarCom Awards for ... , Nerium received a Platinum MarCom Award, the organization’s ... Real Event in St. Louis held in April of ... for more than 14,000 attendees. Additionally, Nerium was awarded ...
(Date:11/26/2014)... SoundConnect , an award winning unified ... that Darren Suders has joined the team as Director ... the partner program through innovative offerings, consistent ... Darren brings more than 10-years of channel telecommunication experience ... operations, from policy development, to partner education and to ...
(Date:11/26/2014)... , Nov. 25, 2014 Bio-Techne Corporation ... has appointed Robert Gavin to serve in ... the Protein Platforms Division.  Mr. Gavin will be responsible ... segment, which includes the ProteinSimple business acquired in July ... San Jose, California -based ProteinSimple develops ...
(Date:11/24/2014)... 2014 Five American winners will ... Maktoum Awards for Medical Sciences", in its 8 th ... Emirates , on 15 December 2014. ... The Carter Center which won the Hamdan Award for ... numerous programs that aim to improve health and promote ...
Breaking Biology Technology:Nerium International™ Wins One Platinum, Two Gold MarCom Awards 2SoundConnect Appoints Director of Channel Development & Sales 2Bio?Techne Announces Appointment Of Robert Gavin As Leader Of New Protein Platforms Division 2Bio?Techne Announces Appointment Of Robert Gavin As Leader Of New Protein Platforms Division 3Five US Winners Among Recipients of Hamdan Medical Awards 2
Cached News: