The opossum genome sequence casts light on evolution, immunity and disease

Genome Research is publishing three papers related to the genome of the gray short-tailed opossum, Monodelphis domestica, a small, nocturnal marsupial found in South America. The papers will appear online on May 10, concomitant with the publication of the opossum genome sequence in the journal Nature.

1. A fresh start for immune-related genes

Like all marsupials, opossums are born without a functioning immune system; they develop immunological tissues, organs, and the ability to produce antibodies outside the shelter of the mother's body. The genome sequence of the opossum--the first for any marsupial--provided Dr. Katherine Belov and her colleagues the opportunity to compare immune-related genes in opossums with those in humans.

Belov's team aligned 1528 human immune-related proteins to the opossum genome, and found that the genetic constituents of the human and opossum "immunomes" were quite similar. "Given the similarities, opossums would make an ideal model organism for developmental immunology studies in mammals, including humans," says Belov.

Katherine Belov, Ph.D.
University of Sydney, Australia

Belov, K., Sanderson, C.E., Deakin, J.E., Wong, E.S.W., Assange, D., McColl, K.A., Gout, A., de Bono, B., Speed, T.P., Trowsdale, J., and Papenfuss, A.T. 2007. Characterization of the opossum immune genome provides insights into the evolution of the mammalian immune system. Genome Res.

2. New functions for ancient DNA

Transposable elements (TEs) are mobile, repetitive DNA sequences that can provide insight into evolutionary processes. "The opossum genome has been bombarded by TEs," explains Dr. Andrew Gentles, the first author on a paper that describes the first comprehensive survey of TE

Contact: Maria Smit
Cold Spring Harbor Laboratory

Page: 1 2 3

Related biology news :

1. Unravelling new complexity in the genome
2. One species, many genomes
3. First genome-wide study of infectious disease opens new avenues for HIV treatment, vaccines
4. Charting ever-changing genomes
5. Neutral evolution has helped shape our genome
6. Sea anemone genome provides new view of our multi-celled ancestors
7. Cloning the male genome may help infertile men
8. Mutating the entire genome
9. Exploring the dark matter of the genome
10. New findings challenge established views on human genome
11. ENCODE map changes view of the human genome landscape

Post Your Comments:

(Date:7/2/2020)... ... July 02, 2020 , ... ... detailing the use of its revolutionary NEXTGENPCR endpoint thermocycler to test for ... minutes. The article, titled "Ultra-fast one-step RT-PCR protocol for the detection of ...
(Date:6/28/2020)... ... June 25, 2020 , ... Genedata, ... that it has entered into a multi-year contract with Merus N.V., a ... translational and clinical research strategy to discover and develop ground-breaking drugs. The ...
(Date:6/23/2020)... FREDERICK, Md. (PRWEB) , ... ... ... a leading provider of gene-to-protein and monoclonal antibody development services, today announced ... of protein-based products and services to the pharmaceutical, diagnostics, and research industries. ...
Breaking Biology News(10 mins):
(Date:8/15/2020)... ... August 13, 2020 , ... True Terpenes , the leading platform for ... Board (SAB) to research the medical potential of terpenes and the potential entourage ... terpenes. The board is focused on expanding the recently launched line of effects-based terpenes ...
(Date:8/12/2020)... ... August 12, 2020 , ... Inc. magazine ... global leader in FDA compliance consulting has been named on its annual Inc. ... list represents a unique look at the most successful companies within the American ...
(Date:7/31/2020)... SCOTTSDALE, Ariz. (PRWEB) , ... July 29, 2020 , ... ... cell joint injections for only $3950. With 50 million stem cells total, patients may ... well stem cell therapy works for arthritic joints (BMC Musculoskelet Disord. 2016). At R3 ...
(Date:7/31/2020)... ... July 29, 2020 , ... Editas Medicine, Inc. (Nasdaq: ... advanced delivery technologies, development, and manufacturing solutions for drugs, biologics, cell and gene ... strategic partnership whereby Catalent will provide support for the development, manufacturing, and clinical ...
Breaking Biology Technology:
Cached News: