The promise of new medical uses for sodium nitrite for heart attack and organ damage

tissue damage and cell death that can occur in conjunction with organ transplantation, heart attack, and treatment of a heart attack.

In both the liver and heart components of the current study, the research team compared the effects of both lower and higher concentrations of nitrite versus control treatments of saline or nitrate, a chemical compound that is related to nitrite but cannot convert to NO in the blood. Surprisingly, they found that only low concentrations of nitrite provided protection against injury.

The investigators are currently studying the mechanism for the protective effect of sodium nitrite and they believe it is related in some way to the conversion of nitrite to nitric oxide.

"The remarkable thing about nitrite is that it is only converted to nitric oxide in the organs and tissues with the lowest oxygen levels, allowing for targeted NO delivery and thus improved blood flow -- to tissues under stress. More research is needed to look at the effectiveness of nitrite in various organs and disease states in humans," said NHLBI's Gladwin who is also an investigator in the Critical Care Medicine Department, NIH Clinical Center.

Gladwin is currently studying the use of sodium nitrite as a way to help adults with sickle cell disease. It is hoped that this treatment will reverse the effect of decreased blood flow due to the patients' "sickled" blood cells. Patients with sickle cell disease have abnormal hemoglobin molecules in their red blood cells. The molecules damage the red cells, causing them to change into a crescent or sickle shape and stick to blood vessel walls. This can lead to narrowed, or blocked, blood vessels leading to pain, damage, and anemia.

Further studies either underway or in planning translate the new findings to humans. These studies evaluate sodium nitrite's effect on heart attacks, kidney failure, solid organ transplantation, cerebral vasospasm (a complication

Contact: NHLBI Communications Office
NIH/National Heart, Lung, and Blood Institute

Page: 1 2 3

Related biology news :

1. Insulin grown in plants relieves diabetes in mice; UCF study holds promise for humans
2. Radiation therapy combined with microsurgery shows promise for curing injured spinal cord
3. New proteomics research promises to revolutionize biomedical discovery
4. New research holds promise for protecting cancer patients against infertility
5. New approach to pulmonary hypertension shows promise
6. Modular leukemia drug shows promise in early testing
7. Hepatitis B drug can compromise HIV treatment
8. UCF nanoparticle offers promise for treating glaucoma
9. Identification of genetic risk factor for coeliac disease promises improved treatment
10. Canadian paper innovation holds promise for improved global health safety
11. Bacteria show promise in fending off global amphibian killer

Post Your Comments:

(Date:1/29/2020)... ... January 29, 2020 , ... INDIGO Biosciences, ... testing solutions, has announced a record earnings year for 2019. With final numbers ... than a twenty percent increase in revenue and a thirty percent increase in ...
(Date:1/28/2020)... ... January 28, 2020 , ... ... improve care efficiency, reduce total cost of care, and limit the utilization of ... healthcare provider group headquartered in San Antonio, Texas specializes in improving care delivery ...
(Date:1/24/2020)... ... 2020 , ... Shoreline Biome , a microbiome research company that develops ... company will debut a novel new DNA isolation kit at the Miami Winter ... Rapid Prep kit, is a fast and easy-to-use kit designed for the efficient and ...
Breaking Biology News(10 mins):
(Date:2/11/2020)... ... February 11, 2020 , ... INSPAN ... a long-term follow-up clinical study of outpatient L4-L5 lumbar interspinous fixation for ... extension block design, the Inspan device fixates the spine to allow for ...
(Date:2/5/2020)... Fla. (PRWEB) , ... February 05, 2020 , ... ... annual observance, sponsored by The National Organization for Rare Disorders (NORD), to raise awareness ... lives ( rarediseaseday.org ). The Balancing Act’s “Behind The Mystery” rare disease ...
(Date:1/28/2020)... ... January 28, 2020 , ... Genedata, ... the release of Genedata Expressionist ® 13.5 at the 2020 WCBP ... Methods (MAM) for characterizing and monitoring the quality of biopharmaceuticals throughout their ...
(Date:1/24/2020)... ... January 24, 2020 , ... The plastic and reconstructive surgeons ... in New Jersey epitomize the notion that plastic surgery is much more than just ... popular media. , Over the last 20 years NJ Top Docs, Dr. Andrew Elkwood, ...
Breaking Biology Technology:
Cached News: