Ricardo Azevedo, an assistant professor in the department of biology and biochemistry, specializes in how evolution changes the way animals develop. His recent findings using computational biology to reveal the surprisingly simple patterns of cell division in the embryos of small invertebrates is described in a paper titled "The Simplicity of Metazoan Cell Lineages," appearing in the current issue of Nature, the weekly scientific journal for biological and physical sciences research.
"The significance of my findings is that these cell lineages are not as complicated as many scientists have thus far believed," Azevedo said. "Our hope is that our approach of treating development as a computer program will help developmental biologists to analyze their favorite organisms."
Since we now understand much about how genes evolve, the attention of biologists like Azevedo has shifted toward elucidating the evolution of developmental mechanisms in the hope of unraveling how evolution modifies more complicated and, therefore, more interesting traits like body size, aging or behavior.
Azevedo and his colleagues constructed an algorithm to contrast the developmental complexity of different organisms based on their sequences of cell divisions, known in the trade as cell lineages. They compared the known cell lineages of three different nematode worms and a sea squirt with those randomly generated by a computer program. They found that the real embryos did not behave like the computer-generated ones, but instead showed that these organisms took fewer "different steps" to fully mature than predicted by chance. In other words, the development of these animals is simpler than it looks.
"It's particularly noteworthy that all four organisms showed the same
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Contact: Lisa Merkl
lkmerkl@uh.edu
713-743-8192
University of Houston
13-Jan-2005